Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LHB contributors: - updated : 08-03-2006
HGNC name luteinizing hormone beta polypeptide
HGNC id 6584
Corresponding disease
LHB fertile eunuchoidism, hypogonadotropic hypogonadism
Location 19q13.3      Physical location : 49.519.237 - 49.520.347
Genatlas name see CGB@
Synonym name lutropin, beta chain
Synonym symbol(s) CGB4, LSH-B
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
PPP1R15A 19q13.2 protein phosphatase 1, regulatory (inhibitor) subunit 15A TULP2 19q13.1 tubby like protein 2 NUCB1 19q13.32 nucleobindin 1 DHDH 19q13.3 dihydrodiol dehydrogenase (dimeric) BAX 19q13.3-q13.4 BCL2-associated X protein FTL 19q13.3 ferritin, light polypeptide GYS1 19q13.3 glycogen synthase 1 (muscle) RUVBL2 19q13.3 RuvB-like 2 (E. coli) LHB 19q13.3 luteinizing hormone beta polypeptide CGB 19q13.3 chorionic gonadotropin, beta polypeptide NTF6A 19q13.3 neurotrophin 6, alpha pseudogene NTF6G 19q13.3 neurotrophin 6, gamma pseudogene CGB2 19q13.32 chorionic gonadotropin, beta polypeptide 2 CGB1 19q13.32 chorionic gonadotropin, beta polypeptide 1 NTF6B 19q13.3 neurotrophin 6, beta pseudogene CGB5 19q13.32 chorionic gonadotropin, beta polypeptide 5 CGB8 19q13.32 chorionic gonadotropin, beta polypeptide 8 CGB7 19q13.32 chorionic gonadotropin, beta polypeptide 7 NTF5 19q13.3 neurotrophin 5 (neurotrophin 4/5) KCNA7 19q13.4 potassium voltage-gated channel, shaker-related subfamily, member 7 SNRP70 19q13.3 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen) LIN7B 19q13.3 lin-7 homolog B (C. elegans) FLJ10490 19q13.33 hypothetical protein FLJ10490 PPFIA3 19q13.3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 HRC 19q13.3 histidine rich calcium binding protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
 neuroendocrinepituitary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY glycoprotein hormone beta chain family
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • promoting spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHB
    Susceptibility
    Variant & Polymorphism other with a common genetic variant-leading in the heterozygous or homozygous type to slight but significant alterations in ovarian steroidogenesis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS