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FLASH GENE
Symbol LHB contributors: - updated : 08-03-2006
HGNC name luteinizing hormone beta polypeptide
HGNC id 6584
Corresponding disease
LHB fertile eunuchoidism, hypogonadotropic hypogonadism
Location 19q13.3      Physical location : 49.519.237 - 49.520.347
Genatlas name see CGB@
Synonym name lutropin, beta chain
Synonym symbol(s) CGB4, LSH-B
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
 neuroendocrinepituitary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY glycoprotein hormone beta chain family
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • promoting spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LHB
    Susceptibility
    Variant & Polymorphism other with a common genetic variant-leading in the heterozygous or homozygous type to slight but significant alterations in ovarian steroidogenesis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS