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FLASH GENE

Symbol

LHB

contributors: mct - updated : 12-10-2022

HGNC name	luteinizing hormone beta polypeptide
HGNC id	6584

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HH23 hypogonadotropic hypogonadism 23 with or without anosmia
Location	19q13.33      Physical location : 49.519.237 - 49.520.347
Genatlas name	see CGB@
Synonym name	lutropin, beta chain
Synonym symbol(s)	CGB4, LSH-B

DNA

TYPE	functioning gene
STRUCTURE	3.52 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000894 3 - 525 NP_000885 - 141 - 2020 32475064

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary         neuroendocrine pituitary

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

glycoprotein hormone beta chain family

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION

promoting spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity

INTERACTION

DNA

RNA

small molecule

protein

upstream region of LHB is one of the target sites for glucoprivation inducing AMPK activation, and AMPK plays a role in repressing LHB expression through the distal -2527 to -2198b region

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HH23

Susceptibility

to variation on the outcomes of in vitro fertilisation (IVF) and embryo transfer

Variant & Polymorphism other	with a common genetic variant-leading in the heterozygous or homozygous type to slight but significant alterations in ovarian steroidogenesis
	Trp8Arg polymorphism of the LHB gene has decreased bioactivity and a role on the IVF outcome

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS