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FLASH GENE
Symbol LGR6 contributors: mct - updated : 25-04-2012
HGNC name leucine-rich repeat-containing G protein-coupled receptor 6
HGNC id 19719
Location 1q32.1      Physical location : 202.163.117 - 202.288.888
Synonym name gonadotropin receptor
Synonym symbol(s) FLJ14471, GPCR, VTS20631
DNA
TYPE functioning gene
STRUCTURE 125.77 kb     18 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map D1S1171 - D1S2615 - LGR6 - D1S1727 - LGR6 - D1S1647 - D1S2655
Physical map
TNNI1 1q31.3 troponin I, skeletal, slow PHLDA3 1q31.3-q32.1 pleckstrin homology-like domain, family A, member 3 CSRP1 1q32.1 cysteine and glycine-rich protein 1 LOC388725 1 similar to mKIAA1151 protein NAV1 1q32.1 neuron navigator 1 IPO9 1q31.3 importin 9 LOC149345 LMOD1 1q32 leiomodin 1 (smooth muscle) TIMM17A 1q31.3-q32 translocase of inner mitochondrial membrane 17 homolog A (yeast) LOC391151 1 similar to 60S ribosomal protein L10 (QM protein homolog) RNPEP 1q32.1-q32.2 arginyl aminopeptidase (aminopeptidase B) ELF3 1q32.2 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) ET(B)R-LP-2 1q32.1 endothelin type b receptor-like protein 2 LOC127829 PTPN7 1q32.1 protein tyrosine phosphatase, non-receptor type 7 LOC388726 1 similar to osteotesticular protein tyrosine phosphatase LOC148713 1q32.1 similar to Osteotesticular phosphatase; protein tyrosine phosphatase, receptor type, V LGR6 1q32.1 leucine-rich repeat-containing G protein-coupled receptor 6 HSPC150 1q32.1 HSPC150 protein similar to ubiquitin-conjugating enzyme PPP1R12B 1q32.1 protein phosphatase 1, regulatory (inhibitor) subunit 12B HCP4 1q32.1 cytochrome c, somatic pseudogene SYT2 1q31.3 synaptotagmin II PLU-1 1q32.1 putative DNA/chromatin binding motif LOC388727 1 LOC388727 LOC163556 1q32.1 similar to RIKEN cDNA 4931440L10 LOC391152 1 similar to Tubulin alpha-2 chain (Alpha-tubulin 2) LOC388728 1 similar to alpha tubulin LOC391153 1 similar to actin RABIF 1q32-q41 RAB interacting factor C3IP1 1q32.1 kelch-like protein C3IP1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 splicing 3458 104.2 967 - 2000 10935549
18 splicing 3345 99.2 915 - 2000 10935549
  • containing an alternate in-frame exon in the 5' coding region compared to variant 1
  • using a downstream start codon compared to variant 1
  • 16 splicing 3041 89.2 828 - 2000 10935549
  • containing an alternate in-frame exon in the 5' coding region compared to variant 1
  • useing a downstream start codon compared to variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal extracellular domain (ECD) composed of 17 leucine-rich repeats
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Lgr6 (90.7 pc)
    homolog to murine Lgr6 (90.2 pc)
    Homologene
    FAMILY
  • G protein-coupled 7-transmembrane protein superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a glycoprotein hormone receptor
  • potentially marks the most primitive epidermal stem cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • each of the four R-spondins, secreted Wnt pathway agonists, can bind to LGR4, LGR5 and LGR6
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage probably by ATM or ATR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS