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FLASH GENE
Symbol LGR6 contributors: mct - updated : 25-04-2012
HGNC name leucine-rich repeat-containing G protein-coupled receptor 6
HGNC id 19719
Location 1q32.1      Physical location : 202.163.117 - 202.288.888
Synonym name gonadotropin receptor
Synonym symbol(s) FLJ14471, GPCR, VTS20631
DNA
TYPE functioning gene
STRUCTURE 125.77 kb     18 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map D1S1171 - D1S2615 - LGR6 - D1S1727 - LGR6 - D1S1647 - D1S2655
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 splicing 3458 104.2 967 - 2000 10935549
18 splicing 3345 99.2 915 - 2000 10935549
  • containing an alternate in-frame exon in the 5' coding region compared to variant 1
  • using a downstream start codon compared to variant 1
  • 16 splicing 3041 89.2 828 - 2000 10935549
  • containing an alternate in-frame exon in the 5' coding region compared to variant 1
  • useing a downstream start codon compared to variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal extracellular domain (ECD) composed of 17 leucine-rich repeats
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Lgr6 (90.7 pc)
    homolog to murine Lgr6 (90.2 pc)
    Homologene
    FAMILY
  • G protein-coupled 7-transmembrane protein superfamily
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a glycoprotein hormone receptor
  • potentially marks the most primitive epidermal stem cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • each of the four R-spondins, secreted Wnt pathway agonists, can bind to LGR4, LGR5 and LGR6
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage probably by ATM or ATR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS