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FLASH GENE
Symbol LGALS8 contributors: mct - updated : 25-09-2013
HGNC name lectin, galactoside-binding, soluble, 8 (galectin 8)
HGNC id 6569
Location 1q42.3      Physical location : 236.681.564 - 236.712.996
Synonym name
  • prostate carcinoma tumor antigen 1
  • po66 carbohydrate-binding protein
  • Synonym symbol(s) PCTA1, LEG8, Po66-CBP, Gal-8, PCTA-1
    DNA
    TYPE functioning gene
    STRUCTURE 34.77 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    MAPPING cloned Y linked N status provisional
    Physical map
    IRF2BP2 1q42.3 interferon regulatory factor 2 binding protein 2 LOC284527 1q42.3 hypothetical gene supported by BC016972 TOMM20 1q42 hypothetical gene supported by BC016972 KIAA0117 1q42.3 KIAA0117 protein RBP1L1 1q42.1-q43 retinoblastoma binding protein 1-like 1 GGPS1 1q43 geranylgeranyl diphosphate synthase 1 TBCE 1q42.3 tubulin-specific chaperone e MGC39558 1q42.3 hypothetical protein MGC39558 GNG4 1q42.3 guanine nucleotide binding protein (G protein), gamma 4 CHS1 1q42.1-q42.2 Chediak-Higashi syndrome 1 NID 1q43 nidogen (enactin) LOC343508 1q42.3 similar to aconitase 2 TM7SF1 1q42-q43 transmembrane 7 superfamily member 1 (upregulated in kidney) ERO1LB 1q42.2-q43 ERO1-like beta (S. cerevisiae) EDARADD 1q42.3 EDAR-associated death domain ENO1P 1q41-q42 enolase 1, (alpha) pseudogene LGALS8 1q42-q43 lectin, galactoside-binding, soluble, 8 (galectin 8) FLJ10359 1q42.3 protein BAP28 ACTN2 1q42-q43 actinin, alpha 2 MTR 1q43 5-methyltetrahydrofolate-homocysteine methyltransferase LOC388754 1 similar to 60S ribosomal protein L35 RYR2 1q42.1-q43 ryanodine receptor 2 (cardiac) ZP4 1q43 zona pellucida glycoprotein 4 LOC391178 1 hypothetical gene supported by AL122093
    RNA
    TRANSCRIPTS type messenger
    text multiple expression isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 6151 - 359 - 2004 14758080
    12 - 6281 - 359 - 2004 14758080
    11 - 6155 - 317 - 2004 14758080
    10 - 6212 - 317 - 2004 14758080
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Reproductivefemale systemplacenta    Homo sapiens
    Respiratoryrespiratory tractlarynx   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    cell lineage
    cell lines prostate and lung carcinoma
    fluid/secretion
    at STAGE
    Text expressed by villous and extravillous cytotrophoblast
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N and C terminal carbohydrate-binding domains connected by a link peptide, N terminal contains a unique WGEI motif instead of the consensus WG-E-R/K motif (role in sugar binding)
  • two covalently linked carbohydrate recognition domains (CRDs)
  • HOMOLOGY
    interspecies ortholog to rattus Lgals8
    intraspecies homolog to LGALS4
    Homologene
    FAMILY beta galactoside binding protein family (galaptin family)
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • cytosolic lectin
  • basic FUNCTION
  • involved in cellular interactions and neoplastic transformation (inintegrin-like cell interaction)
  • role for LGALS8 and PDPN in supporting the connection of the lymphatic endothelium to the surrounding extracellular matrix, most likely in cooperation with other glycoproteins on the surface of lymphatic endothelial cells
  • potent platelet activator, supporting a role for this lectin in thrombosis and inflammation
  • critical role for this lectin in the regulation of capillary-tube formation and endothelial cell migration
  • essential role for LGALS8 in the regulation of angiogenesis with critical implications in tumor biology
  • novel function in activating RHO signaling in TM (trabecular meshwork) cells, function that may allow LGALS8 to participate in the regulation of aqueous outflow
  • serves potentially as a versatile receptor for vesicle-damaging pathogens
  • danger receptor LGALS8, by recruiting CALCOCO2, directs autophagy towards invading bacteria
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor-ligand relationships between CD44 and LGALS8, interactions which may affect the extent of the autoimmune inflammatory response in the synovial fluid of rheumatoid arthritis patients
  • primary target of LGALS8 must be the sugar chains on members of the integrin family, which are abundantly expressed on the surface of leucocytic cells
  • by recruiting CALCOCO2, galectin 8 activates antibacterial autophagy
  • danger receptor that senses cytosolic host glycans and recruits CALCOCO2 to restrict Salmonella proliferation
  • LGALS8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS