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FLASH GENE

Symbol

LGALS7

contributors: mct - updated : 25-05-2011

HGNC name	lectin, galactoside-binding, soluble, 7 (galectin 7)
HGNC id	6568

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.2      Physical location : 39.261.607 - 39.264.157
Synonym symbol(s)	HKL14, LEG7, GAL7, PIG1

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain         Reproductive male system prostate       Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY	galaptin (s-lectin) family
	family of beta-galactoside-binding lectins

CATEGORY

adhesion , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	a fraction of LGALS7 is constitutively localized at mitochondria in a BCL2-dependent manner and sensitizes the mitochondria to the apoptotic signal

basic FUNCTION	involved in cell-cell and / or cell-matrix interactions necessary for normal growth control
	arterial intima-enriched (AIE) gene, with periplakin, SPRR3, envoplakin, galectin 7, and plakoglobin that are functionally related in that they contribute to the stress properties of stratified epithelium
	exhibit a pro-apoptotic function, as a new mitochondrial BCL2 interacting partner

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding of LGALS7 to BCL2 may constitute a new target for enhancing the intrinsic apoptosis pathway

cell & other

REGULATION

Other

regulated by prolonged cyclic stress in vascular smooth muscle cells, which may have important implications to vascular disease

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS