Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LGALS4 contributors: mct - updated : 02-04-2020
HGNC name lectin, galactoside-binding, soluble, 4
HGNC id 6565
Location 19q13.2      Physical location : 39.292.311 - 39.303.740
Synonym name
  • galectin 4
  • lectin, galactoside-binding, soluble, 4 (galectin 4)
  • antigen NY-CO-27
  • L-36 lactose-binding protein
  • Synonym symbol(s) GAL4, L36LBP
    DNA
    TYPE functioning gene
    STRUCTURE 11.94 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1121 35.9 323 - 2017 28947766
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus     Homo sapiens
     intestinelarge intestinecolon   Homo sapiens
     intestinesmall intestine    Homo sapiens
     mouthtongue    Homo sapiens
     stomach     Homo sapiens
    Nervousbrainlimbic systemhippocampus   Homo sapiens
     brainforebraincerebral cortex   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal carbohydrate-recognition domain
  • two carbohydate binding domains
  • C-terminal carbohydrate recognition domain, involved in recognition of glycosphingolipids, sulfated saccharides and blood group antigens
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the assembly of adherens junction
  • plays a unique role in the intestine and assign a novel role of this protein in controlling intestinal inflammation by a selective induction of T cell apoptosis and cell cycle restriction
  • tandem-repeat-type galectin that is expressed in the epithelium of the alimentary tract from the tongue to the large intestine
  • involved in epithelial glycoprotein transport
  • is required for axon growth and for the organization of axonal membrane L1 delivery and clustering
  • plays an important role in metastatic process of lung adenocarcinoma
  • role of LGALS4 and other galectins in basolateral to apical epithelial transcytosis
  • may function as a tumor suppressor gene in urothelial carcinoma (UC) progression, and methylation-mediated LGALS4 gene repression may be involved in urothelial tumor progression
  • neurons establish axon membrane domains expressing LGALS4, the first inhibitor of myelination identified in axons, whose regulated boundaries delineate myelination-incompetent axon segments along development
  • may likely exert the immunoregulatory functions through the activation and differentiation of monocytes
  • played a critical role in the progression of urothelial carcinoma of the bladder
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LGALS4 interacts with the drug transporter SLC28A3 to regulate its function
  • could bind to CD14 on monocytes and induce their differentiation into macrophage-like cells through the MAPK signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal and hepatocellular carcinomas
    tumoral       gain of function
    in Bladder cancer patients when compared with normal subjects
    tumoral     --low  
    is a predictor of worse prognosis in pancreatic cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for a soluble regulator of oligodendrocytes (OLGs) differentiation and, hence, myelination (
  • Marker
  • potential biomarker for diagnosis and treatment of urothelial carcinoma of the bladder
  • LGALS3, LGALS4 may be potential noninvasive markers for the identification of Parkinson disease and advanced stages
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    is a novel anti-inflammatory agent that could be therapeutically effective in diseases with a disturbed T cell expansion and apoptosis such as inflammatory bowel disease
    ANIMAL & CELL MODELS