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FLASH GENE
Symbol LGALS3BP contributors: mct/npt - updated : 22-04-2010
HGNC name lectin, galactoside-binding, soluble, 3 binding protein
HGNC id 6564
Location 17q25.3      Physical location : 76.967.335 - 76.976.061
Synonym name
  • L3 antigen
  • Mac-2-binding protein
  • tumor-associated antigen 90K
  • basement membrane autoantigen p1053
  • serum protein 90K
  • galectin 3 binding protein
  • Synonym symbol(s) 90K, MAC-2-BP, TAA90K, BTBD17B, MAC2BP, M2BP
    DNA
    TYPE functioning gene
    STRUCTURE 8.73 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2277 - 585 - Calabrese (1995)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines lung carcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one BTB (poz) domain
  • a SRCR domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in immune response associated with natural killer and lymphokine activated killer cell cytotoxicity
  • implicated in cancer progression and metastasis (Ulmer 2006)
  • may be contributing to colon cancer progression is by modulating tumor cell adhesion to extracellular proteins, including galectin-3 (Ulmer 2006)
  • factor secreted by neuroblastoma cells that stimulates the expression of interleukin-6 in bone marrow stromal cells, that may have a novel function for this protein in cancer progression (Fukaya 2008)
  • matricellular protein with a role in tumor progression and metastasis, that is a novel reliable indicator of prognosis in tumor (in Ewing sarcoma)(Zambelli 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • galactoside-beta binding
  • specific interaction partner of CD248 (Becker 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer in progression with poor prognosis and liver metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS