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FLASH GENE
Symbol LGALS1 contributors: mct - updated : 03-01-2015
HGNC name lectin, galactoside-binding, soluble, 1
HGNC id 6561
Location 22q13.1      Physical location : 38.071.612 - 38.075.807
Synonym name
  • beta-galactoside-binding lectin
  • galectin 1
  • lactose-binding lectin 1
  • putative MAPK-activating protein PM12
  • galaptin
  • 14 kDa laminin-binding protein
  • Synonym symbol(s) GBP, HPL, HLBP14, gal-1, DKFZp686E23103, GAL1
    DNA
    TYPE functioning gene
    STRUCTURE 4.20 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 586 14.7 135 - 2000 10728371
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunethymus    
    Nervousnervecranial nerve  highly Homo sapiens
    Skin/Tegumentskin   highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly Homo sapiens
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    Nervousastrocyte Homo sapiens
    Nervousglia Homo sapiens
    Nervousneuron
    Skeletonosteoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single carbohydrate-recognition domain, recently identified as being overexpressed in tumor-associated capillary endothelial cells
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • galectin (galaptin/s-lectin) family
  • beta-galactoside-binding proteins family
  • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in vascular smooth muscle cell proliferation
  • may be regulating cell apoptosis and cell differentiation
  • regulating tumor angiogenesis
  • can directly bind to NRP1 on endothelial cells, and can promote the NRP1/KDR-mediated signaling pathway as well as NRP1-mediated biological activities
  • induces phosphatidylserine exposure independent of alterations in mitochondrial potential, caspase activation, or cell death
  • stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages
  • may be involved in chemoattraction at sites of inflammation and may contribute to disease processes such as atherosclerosis
  • inhibits retinal pigment epithelial cell attachment, spreading, and migration
  • mediate inflammation and involved in axonal regeneration in the oxidized form and in axonal degeneration in the reduced form
  • may be associated with the pathogenesis of spinal cord injury
  • plays an important role in mesenchymal stromal cells immunoregulatory functions, which are depending on cell environment
  • LGALS1 and CD69 are a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to extracellular matrix proteins
  • binds LGALS3BP
  • selectively bound NRP1 via the carbohydrate-recognition domain, but did not bind FLT1, FLT4, KDR
  • is a novel ligand for MCAM and this interaction protects, in vitro, endothelial cells against apoptosis induced by LGALS1
  • prominent immunoregulatory function of LGALS1, is induction of apoptosis in activated T-cells by a process depending on the activity of SRC family tyrosine kinase, LCK
  • LGALS1 induces vascular permeability through the NRP1/FLT1 complex
  • interaction of LGALS1 and LGALS3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology
  • LGALS1, which encodes the galectin-1 protein, was a potential target of LYAR
  • cell & other
  • binding stronger to vascular smooth muscle cells
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in hepatocellular carcinoma involving methylation -sensitive complex formation at the transcriptional upstream and downstream elements
    tumoral     --over  
    in endothelial cells of different tumors
    tumoral     --over  
    in the tumor-associated endothelial cells of oral squamous cell carcinomas
    tumoral     --over  
    is a predictor of worse prognosis in pancreatic cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene target for angiostatic cancer therapy
    Marker
  • powerful diagnostic marker that distinguishes chondroblastic osteosarcomas from conventional chondrosarcomas
  • Therapy target
  • may serve as a potential diagnostic marker or therapeutic target for nasopharyngeal carcinoma
  • ANIMAL & CELL MODELS