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FLASH GENE
Symbol LEUTX contributors: mct - updated : 10-04-2020
HGNC name leucine twenty homeobox
HGNC id 31953
Location 19q13.2      Physical location : 40.267.233 - 40.276.773
DNA
TYPE anonymous DNA segment
SPECIAL FEATURE arranged in tandem
STRUCTURE 9.54 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 672 - 168 - 2016 27578796
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved domains, the homeodomain,
  • and a Leutx-specific domain containing putative transcriptional activation motifs (9aaTAD)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text
  • expression level for all five genes (ARGFX, DPRX, LEUTX, TPRX1) crashes after the morula stage, and the genes are not strongly expressed again in embryonic, foetal or adult tissues
  • nuclear-localised but with evidence of disruption to cell integrity
  • basic FUNCTION
  • LEUTX arose on the primate lineage
  • may have originated by tandem duplication from the CRX gene in the Otx gene family, or from the mammalian TPRX1 gene which itself may have originated from CRX
  • ARGFX, TPRX1 LEUTX, DPRX genes arose by asymmetric evolution from the CRX homeobox gene at the base of eutherian evolution, as part of a dynamic series of duplications
  • partial overlap of function between LEUTX and TPRX1
  • ETCHbox (Eutherian Totipotent Cell Homeobox) gene
  • ARGFX, LEUTX and TPRX1 regulate a set of developmentally-important genes precisely modulated at the time when the earliest cell fate decisions are made
  • paired (PRD)-like homeobox gene that is expressed almost exclusively in human embryos during preimplantation development
  • acts as a TAATCC-targeting transcriptional activator, like other K50-type PAIRED-LIKE transcription factors (TF)
  • functions as a transcriptional activator important for human embryogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LEUTX and TPRX1 genes act on a similar set of genes and genetic pathways between the 4-cell stage and the blastocyst, in an antagonistic manner to the effects of ARGFX
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused to the KAT6A gene on 8p11 in a therapy-related AML with t(8;19)(p11;q13) ( fused to the KATon 8p11 in a therapy-related AML with t(8;19)(p11;q13)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS