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FLASH GENE
Symbol LEPROTL1 contributors: mct/npt - updated : 21-10-2014
HGNC name leptin receptor overlapping transcript-like 1
HGNC id 6555
Location 8p12      Physical location : 29.952.921 - 29.995.222
Synonym name
  • endospanin-2
  • Synonym symbol(s) MYO47, Vps55, HSPC112
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping, gene in gene
    STRUCTURE 42.30 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2721 14.4 131 - 2001 11342119
    4 - 821 - 169 - 2001 11342119
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • JAK binding site (Pro (46)-Ile-Pro(48) preceded by a cluster of hydropobic residues)
  • four potential transmembrane domains
  • HOMOLOGY
    intraspecies homolog to LEPR
    Homologene
    FAMILY
  • OB-RGRP/VPS55 family
  • tetraspanning membrane proteins family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • with LEPROT influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism (Touvier 2009)
  • LEPROT and LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF21 prevents the GH effects on chondrocytes by activating LEPROT and LEPROTL1
  • FGF21 specifically and directly modulate LEPROT/LEPROTL1 expression and function in chondrocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS