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FLASH GENE
Symbol LEPROT contributors: mct/npt - updated : 21-10-2014
HGNC name leptin receptor overlapping transcript
HGNC id 29477
Location 1p31.3      Physical location : 65.886.247 - 65.901.688
Synonym name
  • leptin receptor gene related protein
  • OB-R gene-related protein
  • DnaJ (Hsp40) homolog, subfamily C, member 6
  • endospanin-1
  • Synonym symbol(s) LEPR, VPS55, OBRGRP, OB-RGRP, FLJ90360
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping
    STRUCTURE 15.56 kb     4 Exon(s)
    regulatory sequence Promoter
    text structure promoter potentially regulates the transcription of both LEPROTand LEPR mRNA (Satoh 2009)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text containing the first two OB-R gene 5'-untranslated exons, but then is alternatively spliced to two novel exons which were mapped to a yeast artificial chromosome containing the leptin receptor gene
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4663 13.12 131 - Bailleul (1997)
    3 - 611 - 37 - -
    2 - 4161 - 1165 - -
    2 - 5142 - 895 - -
    2 - 3079 - 958 - -
    5 - 4625 - 140 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vessel   predominantly
    Digestiveliver   highly Homo sapiens
    Reproductivefemale systemuterus  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four potential transmembrane domains
  • HOMOLOGY
    interspecies ortholog to rattus Obrgrp
    ortholog to murine Obrgrp
    Homologene
    FAMILY
  • OB-RGRP/VPS55 family
  • tetraspanning membrane proteins family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediates the weight-regulatory effects of leptin (OB protein)(Bailleul 1997)
  • with LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism (Touvier 2009)
  • LEPROT and LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF21 prevents the GH effects on chondrocytes by activating LEPROT and LEPROTL1
  • FGF21 specifically and directly modulate LEPROT/LEPROTL1 expression and function in chondrocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS