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FLASH GENE
Symbol LEO1 contributors: mct - updated : 17-04-2014
HGNC name Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
HGNC id 30401
Location 15q21.2      Physical location : 52.230.224 - 52.263.958
Synonym name
  • replicative senescence down-regulated Leo1-like gene
  • senescence downregulated leo1-like
  • RNA polymerase-associated protein LEO1
  • Synonym symbol(s) RDL
    DNA
    TYPE functioning gene
    STRUCTURE 33.78 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2162 - 666 - -
    10 - 2022 - 606 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     pharynx   highly
     stomach   highly
    Endocrineadrenal gland   highly
    Reproductivefemale systembreastmammary gland moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Leo1-like domain, a senescence-associated domain that accelerates the senescence of 2BS fibroblasts
  • mono polymer heteromer , dimer , complex
    HOMOLOGY
    Homologene
    FAMILY
  • LEO1 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • potential requirement for LEO1 in the development of the heart and neural crest cell populations
  • LEO1, but not RTF1, is necessary for the complex to bind RNA
  • cells lacking LEO1 have reduced PAF1C recruitment as well as decreased levels of histone H3 and trimethylated H3 Lys within transcribed chromatin
  • RTF1, CDC73, and LEO1 have all been shown to play a role in recruitment of PAF1C to chromatin at active genes
  • CELLULAR PROCESS cell life, senescence
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with CDC73, PAF1, SH2BP1, RTF1
  • PAF1 and LEO1 subunits form a tightly associated heterodimer through antiparallel beta-sheet interactions 8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with beta-catenin in the Wnt pathway (Bralten 2010)
  • LEO1 is a novel and important mediator of PTP4A3 oncogenic activities in Acute Myeloid Leukemia (AML)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with SLC12A1 in glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS