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FLASH GENE
Symbol LECT2 contributors: mct - updated : 24-03-2012
HGNC name leukocyte cell-derived chemotaxin 2
HGNC id 6550
Location 5q31.1      Physical location : 135.282.599 - 135.290.723
Synonym name chondromodulin-II
Synonym symbol(s) MGC126628, chm-II, chm2
DNA
TYPE functioning gene
STRUCTURE 8.12 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
FLJ37562 5q31.2 hypothetical protein FLJ37562 FLJ22625 5q31.2 hypothetical protein FLJ22625 DCOHM 5q31.2 hypothetical protein FLJ22625 CATSPER3 5q31.2 cation channel, sperm associated 3 PITX1 5q31 paired-like homeodomain transcription factor 1 LOC389328 5 LOC389328 LOC389329 5 LOC389329 H2AFY 5q31.3-q32 H2A histone family, member Y DCNP1 5q31.2 dendritic cell nuclear protein 1 LOC345607 5q31.2 similar to FLJ00292 protein NEUROG1 5q23-q31 neurogenin 1 CXCL14 5q31 chemokine (C-X-C motif) ligand 14 LOC389330 5 LOC389330 LOC389331 5 LOC389331 LOC153328 5q31.2 similar to CG4995 gene product IL9 5q31.1 interleukin 9 FBXL3B 5q31 F-box and leucine-rich repeat protein 3B LECT2 5q31.1-q32 leukocyte cell-derived chemotaxin 2 TGFBI 5q31.1 transforming growth factor, beta-induced, 68kDa DAMS 5q31.1 SMAD in the antisense orientation MADH5 5q31.1 MAD, mothers against decapentaplegic homolog 5 (Drosophila) LOC389332 5 hypothetical gene supported by BC048329 TRPC7 5q31.2 transient receptor potential cation channel, subfamily C, member 7 LOC391834 5 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC391835 5 similar to Hypothetical protein FLJ20189 SPOCK 5q31 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1077 - 151 - 1998 9545637
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   specific
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to bovine chondromodulin II,growth stimulator of chondrocyte cells
Homologene
FAMILY LECT2/MIM-1 family
CATEGORY signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • having neutrophil chemotactic activity and also involved in growth and differentiation of myeloid cells
  • positive regulator of chondrocyte proliferation
  • protein with chemotactic properties for neutrophils, and is a direct target gene of Wnt/beta-catenin signaling in the liver
  • participates in regeneration after injury of hepatocytes
  • potentially regulates neuritic extension through microtubular morphallaxis through the control of KATNA1 levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by by phytohemagglutinin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in advanced hepatocellular carcinoma
    constitutional germinal mutation      
    in renal amyloidosis (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • candidate prognostic marker of hepatocellular carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    therapeutic strategies targeting LECT2 expression is a promising therapy for human HCC
    ANIMAL & CELL MODELS