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FLASH GENE
Symbol LDOC1 contributors: mct - updated : 05-12-2011
HGNC name leucine zipper, down-regulated in cancer 1
HGNC id 6548
Location Xq27.2      Physical location : 140.269.939 - 140.271.310
Synonym name breast cancer, up-regulated 1
Synonym symbol(s) BCUR1, Mar7, Mart7
DNA
TYPE functioning gene
STRUCTURE 1.38 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
SRD5AP1 Xq24-qter steroid-5-alpha-reductase, alpha polypeptide pseudogene 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha pseudogene) F9 Xq26.3-q27.1 coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) MCF2 Xq26.3-q27.1 MCF.2 cell line derived transforming sequence BCYRN1P1  brain cytoplasmic RNA 1, pseudogene 1 ATP11C X ATPase, Class VI, type 11C LOC347487 Xq27.1 hypothetical LOC347487 LOC389893 X LOC389893 LOC389894 X hypothetical gene supported by NM_194247 LOC389895 X similar to PRO0149 protein LOC389896 X LOC389896 LOC266694 Xq27.1 embryonic ectoderm development pseudogene SOX3 Xq27.1 SRY (sex determining region Y)-box 3 CDR1 Xq27.1-q27.2 cerebellar degeneration-related protein 1, 34kDa SPANXB1 Xq27.1 SPANX family, member B1 dJ507I15.1 Xq27.1 ribosomal protein L36a pseudogene LDOC1 Xq27.2 leucine zipper, down-regulated in cancer 1 SPANXC Xq27.1 SPANX family, member C NDUFB3P5  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 5 SPANXA1 Xq27.1 sperm protein associated with the nucleus, X chromosome, family member A1 LOC389897 X hypothetical gene supported by BC042039 SPANXE Xq27.1 SPANX family, member E SPANXD Xq27.1 SPANX family, member D MAGEC3 Xq27.2 melanoma antigen, family C, 3 MAGEC1 Xq26 melanoma antigen, family C, 1 LOC392554 X similar to melanoma antigen, family A, 10; melanoma-associated antigen 10; MAGE-10 antigen LOC392555 X similar to Melanoma-associated antigen E1 (MAGE-E1 antigen) (MAGE-C2 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen CT10) LOC139075 Xq27.2 similar to Melanoma-associated antigen E1 (MAGE-E1 antigen) (MAGE-C2 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen CT10) MAGEE1 Xq27 melanoma antigen, family E, 1, cancer/testis specific
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1388 17 146 - 2011 21310924
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   lowly
Endocrinethyroid   highly
Nervousbrain   highly
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines breast cancer cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta lowly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • leucine zipper-like motif at the N terminal
  • a proline-rich region (marked similarity to a SH3 binding domain)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a possible role in transcriptional regulation
  • product may have an important role in the development and/or progression of some cancers
  • regulator of the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB)
  • may play a role in normal B-cell development
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text negative control of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with MZF1 (enhancing the activity of LDOC1 for inducing apoptosis)
  • binds directly to the verprolin homology domain of WASF3
  • cell & other
    REGULATION
    inhibited by negatively regulated by WASF3
    Other down-regulated in some cancer cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in some cancer cell lines(in pancreatic cancer)
    constitutional     --over  
    caused externalization of the cell membrane phosphatidylserine, which was characteristic for early-phase apoptotic events, and reduced cell viability in some human cell lines
    tumoral     --low  
    dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LDOC1 mRNA expression is an excellent predictor of overall survival in untreated chronic lymphocytic leukemia patients
  • Therapy target
    ANIMAL & CELL MODELS