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FLASH GENE
Symbol LDLRAD3 contributors: mct - updated : 26-01-2010
HGNC name low density lipoprotein receptor class A domain containing 3
HGNC id 27046
Location 11p13      Physical location : 35.965.611 - 36.252.841
Synonym symbol(s) LOC143458, LRAD3
DNA
TYPE functioning gene
STRUCTURE 287.23 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2969 50 345 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ectodomain containing three LDLa repeats
  • a transmembrane domain, and a cytoplasmic domain containing a conserved dileucine internalization motif and two polyproline motifs
  • conjugated LipoP
    HOMOLOGY
    Homologene
    FAMILY
  • LDLR family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane receptor
    basic FUNCTION
  • its expression significantly decreases the cellular half-life of mature APP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • influences APP processing, raising the possibility that LRAD3 alters APP function in neurons, including its downstream signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS