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FLASH GENE
Symbol LDHB contributors: mct - updated : 15-05-2020
HGNC name lactate dehydrogenase B
HGNC id 6541
Corresponding disease
LDHBD lactate dehydrogenase B deficiency
Location 12p12.1      Physical location : 21.788.274 - 21.810.789
Synonym name
  • epididymis secretory protein Li 281
  • lactate dehydrogenase H chain
  • renal carcinoma antigen NY-REN-4
    • Synonym symbol(s) TRG-5, HEL-S-281, LDH-B, LDH-HD
    EC.number 1.1.1.27
    DNA
    TYPE functioning gene
    STRUCTURE 22.63 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1336 - 341 - 2019 30923124
    8 - 1303 - 334 - 2019 30923124
    8 - 1558 - 334 - 2019 30923124
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus  highly
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    Visualeyeanterior segmentcornea  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Ldh2
    ortholog to rattus ldhb
    homolog to chicken ldhb
    Homologene
    FAMILY
  • LDH/MDH superfamily
  • LDH family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in anaerobic glycolysis, final step
  • LDHB suppression plays an important role in triggering or maintaining the mitochondrial defects and then contributes to cancer cell invasiveness by inducing CLDN1 protein
  • LDHB is a regulator of cell proliferation in a subset of lung adenocarcinoma
  • LDHB activity is necessary for basal autophagy and cancer cell proliferation not only in oxidative cancer cells but also in glycolytic cancer cells
  • LDHB possess a higher affinity for lactate, preferentially converting lactate to pyruvate, and NAD+ to NADH, when oxygen is abundant
  • is a key glycolytic enzyme that catalyzes the interconversion of pyruvate and lactate
  • role of LDHA and LDHB to control apoptosis and autophagy in tumor cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNFSF11-induced LDHA, LDHB activation stimulates glycolytic and mitochondrial respiratory metabolism, facilitating mature osteoclast formation via osteoclast precursor fusion and NFATC1 signaling
  • TIGAR enhanced the expression of LDHB and the mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) markers, PPARGC1A, and NRF1, during neural stem cells (NSCs) diferentiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LDHBD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in osteosarcoma cell lines
    tumoral     --low  
    in hepatocellular carcinoma (HCC), significantly lower than that in noncancerous tissues
    constitutional       loss of function
    may be closely related with the early onset or progression of age-related hearing loss (ARHL)
    constitutional     --other  
    increased LDHA/LDHB ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LDHB can be considered as a prognostic marker for tumor recurrence and poor overall survival in osteosarcoma
  • LDHB expression is a valuable prognostic biomarker for HCC and that low LDHB expression suggests unfavorable survival outcomes in HCC patients
    • Therapy target
    ANIMAL & CELL MODELS
  • Ldhb knockout mice showed hearing loss at high frequencies, which is the typical feature of age-related hearing loss (ARHL)