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FLASH GENE
Symbol LDHB contributors: - updated : 06-03-2006
HGNC name lactate dehydrogenase B
HGNC id 6541
Corresponding disease
LDHBD lactate dehydrogenase B deficiency
Location 12p12.2-p12.1      Physical location : 21.788.274 - 21.810.789
Synonym symbol(s) TRG-5
EC.number 1.1.1.27
DNA
TYPE functioning gene
STRUCTURE 22.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
PDE3A 12p12 phosphodiesterase 3A, cGMP-inhibited SLCO1C1 12p12.3 solute carrier organic anion transporter family, member 1C1 SLCO1B3 12p12 solute carrier organic anion transporter family, member 1B3 LST-3 12p12.3 liver-specific organic anion transporter 3 SLCO1B1 12p solute carrier organic anion transporter family, member 1B1 SLCO1A2 12p12 solute carrier organic anion transporter family, member 1A2 IAPP 12p12.3-p12.2 islet amyloid polypeptide FLJ22028 12p12.3 hypothetical protein FLJ22028 RECQL 12p12-p11 RecQ protein-like (DNA helicase Q1-like) CGI-141 12p12.3 CGI-141 protein MGC10946 12p12.3 hypothetical protein MGC10946 GYS2 12p12.2 glycogen synthase 2 (liver) LDHB 12p12.2-p12.1 lactate dehydrogenase B KCNJ8 12p11.23 potassium inwardly-rectifying channel, subfamily J, member 8 ABCC9 12p12.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 CMAS 12p13.2 cytidine monophosphate N-acetylneuraminic acid synthetase SIAT8A 12p12.3-p12.2 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) KIAA0528 12p12.2 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) EKI1 12p12.3 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus  highly
Skin/Tegumentskin   highly
Urinarybladder   highly
Visualeyeanterior segmentcornea  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies ortholog to murine Ldh2
ortholog to rattus ldhb
homolog to chicken ldhb
Homologene
FAMILY
  • LDH/MDH superfamily
  • LDH family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION involved in anaerobic glycolysis, final step
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LDHBD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS