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FLASH GENE
Symbol LDB2 contributors: mct/npt - updated : 13-04-2018
HGNC name LIM domain binding 2
HGNC id 6533
Location 4p15.32      Physical location : 16.503.166 - 16.900.424
Synonym name
  • carboxyl-terminal LIM domain,protein 1
  • LIM domain-binding factor CLIM1
  • enigma protein
  • Synonym symbol(s) CLIM1, LDB1
    DNA
    TYPE functioning gene
    STRUCTURE 397.16 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2560 42.66 373 - Tran (2006)
    9 - 2703 37.9 331 - Tran (2006)
  • lacking the LID domain
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PDZ domain at the N-terminal region (Kotaka (2000)
  • LIM domain binding region
  • LIM-interaction domain (LID) in the C-terminal region and encoded by the last exon (exon 10) of LDB genes (Tran 2006)
  • HOMOLOGY
    interspecies homolog to murine Mn8266
    Homologene
    FAMILY
  • LDB family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text colocalizes with alpha-actinin at the Z-disks in myocardium and is a novel cytoskeletal protein (Kotaka 2000)
    basic FUNCTION
  • involved in developmental processes
  • required for LIM-homeodomain proteins to exert their biological activities
  • may act as an adapter that brings other proteins to the cytoskeleton (Kotaka 2000)
  • with LDB2 interact with the Ste20-like Kinase SLK and regulate cell Migration (Storbeck 2009)
  • cytoplasmic protein that is involved with the cytoskeleton and signal transduction pathway (Kotaka 2000)
  • stage-dependent roles of LDB1 and functional redundancy with LDB2 in mammalian retinogenesis (pMID: 27697904)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text neural and other development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA, LIM domain binding
    RNA
    small molecule
    protein
  • LIM-HD proteins (LHXs)
  • interacting with LDB1 (with LDB1 function to maintain SLK in an inactive state before its activation) (Storbeck 2009)
  • interact with alpha-actinin 2 (Kotaka (2000)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in clear cell renal carcinoma with good outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS