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FLASH GENE
Symbol LCT contributors: - updated : 09-10-2006
HGNC name lactase
HGNC id 6530
Corresponding disease
LCT congenital lactase deficiency
Location 2q21      Physical location : 136.545.414 - 136.594.750
Synonym name lactase/phlorizin hydrolase
Synonym symbol(s) LPH, LAC
EC.number 3.2.1.62, 3.2.1.108
DNA
TYPE functioning gene
STRUCTURE 49.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see IL1RN
Physical map
LOC389050 2 LOC389050 LOC389051 2 LOC389051 LOC163336 2q21.2 similar to FLJ10101 protein LOC391445 2 similar to PRED65 LOC389052 2 similar to breast cancer antigen NY-BR-1 LOC391446 2 similar to rRNA intron-encoded homing endonuclease LOC391447 2 similar to zinc finger protein 285 GPR39 2q21 G protein-coupled receptor 39 MGC29643 2q21.2 hypothetical protein MGC29643 NAP5 2q21.2 Nck-associated protein 5 MGAT5 2q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase DKFZP566N034 2q21.3 hypothetical protein DKFZp566N034 ACMSD 2q21.3 aminocarboxymuconate semialdehyde decarboxylase CCNT2 2q21 cyclin T2 FLJ23074 2q21.3 hypothetical protein FLJ23074 DKFZP434B1727 2q21.3 hypothetical protein DKFZp434B1727 R3HDM 2q21.2 R3H domain (binds single-stranded nucleic acids) containing UBXD2 2p14-q21.3 UBX domain containing 2 LCT 2q21 lactase MCM6 2q21 MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) LOC391448 2 similar to hypothetical protein FLJ31434 DARS 2q21-q22.3 aspartyl-tRNA synthetase CXCR4 2q21 chemokine (C-X-C motif) receptor 4 LOC389053 2 similar to heterogeneous nuclear ribonucleoprotein K UBBP1 17p12-p11.2 ubiquitin B pseudogene 1 KIAA1679 2q21-q22 KIAA1679 protein HNMT 2p14-q21.3 histamine N-methyltransferase LOC150498 2q22.1 similar to epsilon isoform of 14-3-3 protein LOC339744 2q22.1 similar to speckle-type POZ protein NXPH2 2q21.1 neurexophilin 2 LOC129560 2q22.1 similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) MRPS18BP2 6q22.33 mitochondrial ribosomal protein S17 pseudogene 5
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrinethyroid    
Lymphoid/Immunethymus    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY glycosylhydrolase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • beta-galactosidase from intestinal mucosa
  • putatively involved in downregulation and DNA binding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LCT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS