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Symbol LCP2 contributors: mct/npt/pgu - updated : 07-06-2013
HGNC name lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
HGNC id 6529
Location 5q35.1      Physical location : 169.675.087 - 169.724.822
Synonym name
  • SH2 domain-containing leukocyte protein of 76 kDa
  • leukocyte protein 76kDa (SLP-76)
  • 76 kDa tyrosine phosphoprotein
  • Synonym symbol(s) SLP76, SLP-76
    TYPE functioning gene
    STRUCTURE 49.73 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ODZ2 5q35.1 odd Oz/ten-m homolog 2 KIBRA 5q35.1 KIBRA protein RARS 5pter-q11 arginyl-tRNA synthetase LOC345630 5q35.1 similar to fibrillarin PANK3 5q35 pantothenate kinase 3 LOC389342 5 similar to 60S ribosomal protein L10 (QM protein homolog) SLIT3 5q35 slit homolog 3 (Drosophila) FLJ20364 5q35.1 hypothetical protein FLJ20364 DOCK2 5q35.1 dedicator of cyto-kinesis 2 FOXI1 5q34 forkhead box I1 LOC345430 5q35.1 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC133874 5q35.1 hypothetical gene LOC133874 LCP2 5q34 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) KCNMB1 5q34 potassium large conductance calcium-activated channel, subfamily M, beta member 1 KCNIP1 5q35.2 Kv channel interacting protein 1 LOC389343 5 LOC389343 GABRP 5q33-q34 gamma-aminobutyric acid (GABA) A receptor, pi RANBP17 5q31 RAN binding protein 17 USP12P1 5q33-q34 ubiquitin specific protease 12 pseudogene 1 TLX3 5q35.1 T-cell leukemia, homeobox 3 LOC391847 5 similar to hypothetical protein LOC391848 5 similar to 60S ribosomal protein L10 (QM protein homolog) NPM1 5q35 nucleophosmin (nucleolar phosphoprotein B23, numatrin) FGF18 5q34 fibroblast growth factor 18 FBXW1B 5q35.1 F-box and WD-40 domain protein 1B STK10 5q35.1 serine/threonine kinase 10 LOC285588 5q35.2 similar to RIKEN cDNA 1700007I06 DC-UbP 5q35.2 dendritic cell-derived ubiquitin-like protein KIAA1295 5q35.2 KIAA1295 protein LOC391849 5 similar to neuralized homolog LOC133539 5q35.2 similar to RIKEN cDNA 1810009O10 DUSP1 5q34 dual specificity phosphatase 1
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 2472 - 533 - 2007 17420479
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Endocrinepancreas   moderately
    Reproductivemale systemprostate  moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    cell lineage cells of hematopoietic origin (peripheral blood leukocytes)
    cell lines
    at STAGE
  • N terminal acidic region with a PEST domain, and tyrosine residues, N-terminal phosphotyrosines, that play a critical role in T-cell adhesion under flow
  • sterile alpha motif
  • 67 AA functional domain within the proline-rich region (P1 domain)
  • a 10 AA-long sequence upstream the GADS binding site, a LCK binding region essential for T cell antigen receptor signaling and normal T cell development and function
  • one SH2 domain at the C terminus that binds to FYB, and MAP4K1
    interspecies homolog to murine Lcp2
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • involved in T cell antigen receptor mediated signaling
  • functioning as an adaptor or scaffold
  • regulating blood and vascular separation (through hematopoietic signaling pathway)
  • involved in controlling the separation of the lymphatic and blood vascular systems
  • required for TCR-induced tyrosine phosphorylation and activation of ITK but was not required for the phosphorylation or activation of ZAP70
  • having dual role in mediating T cell receptor-induced activation of phospholipase C-gamma1 (PLCG1)
  • can exert a cross-regulatory or feedback control on the clustering of ZAP70, an element previously thought to operate exclusively upstream of LCP2
  • regulates the other cytoplasmic kinase and adaptor ZAP-70 and GADS, whereas upstream transmembrane LAT operates independently in the TCR signaling cascade
  • through its protein-binding domains, serves as a platform for the assembly of multiple enzymes and adapter proteins that function together to activate second messengers required for TCR signal propagation
  • novel role in regulating HIV-1 infection in T cells with the potential to develop innovative strategies against HIV-1
  • novel role in CXCR4-mediated T lymphocyte trafficking
  • is an essential signaling component for basophil activation downstream of both FCER1A and the IL3 receptor
    LCP2/GRAP2/NCK1 adaptor protein pathway, implicated in regulation of the actin cytoskeleton by BCR-ABL kinase
  • critical for ITK-SYK activation and is particularly required for the ITK-SYK-dependent phosphorylation of SYK activation loop tyrosines
  • a component
    small molecule
  • binding LAT (linker for activation of T cells by GRAP2 (GADS)
  • GRB2, FYB and PLCG1
  • SYK (interaction required to regulate separation of blood and lymphatic vascular networks)
  • binds to the src homology 3 domain of LCK
  • direct interaction between LCP2 and CD6 was shown by binding both to a phosphorylated peptide
  • interaction with FYB (role for the LCP2-FYB module in LFA1-mediated costimulation in T cells)
  • ongoing physical interaction between LCP2 and ITK is required to maintain ITK in an active conformation
  • ITK-LCP2 interaction in cytokine production
  • associates with PIK3R1 after T cell activation and LAT recruits this complex to the membrane, leading to AKT1 activation
  • cell & other
    Other phosphorylated by TCR coupled tyrosine kinase
    combined phosphorylation of separate tyrosine residues forms the basis of synergistic NK cell activation