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FLASH GENE
Symbol LCP1 contributors: - updated : 24-06-2006
HGNC name lymphocyte cytosolic protein 1 (L-plastin)
HGNC id 6528
Location 13q14.3      Physical location : 46.700.058 - 46.756.459
Synonym name plastin 2
Synonym symbol(s) PLTL, CP64, PLS2, FLJ25423, FLJ26114, FLJ39956, L-PLASTIN
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
FLJ31846 13q14.11 hypothetical protein FLJ31846 FLJ38725 13q14.11 hypothetical protein FLJ38725 LOC283510 13q14.11 similar to Diacylglycerol kinase, zeta 104kDa MGC5590 13q14.11 hypothetical protein MGC5590 LOC387923 13 similar to ribosome associated membrane protein 4 TSC22 13q14 transforming growth factor beta-stimulated protein TSC-22 LOC341659 13q14.11 similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1 NUFIP1 13q14 nuclear fragile X mental retardation protein interacting protein 1 LSR7 13q13-q14 lipopolysaccharide specific response-7 protein GTF2F2 13q14 general transcription factor IIF, polypeptide 2, 30kDa KCTD4 13q14.12-q14.13 potassium channel tetramerisation domain containing 4 TPT1 13q14.1-q14.2 tumor protein, translationally-controlled 1 LOC338851 13q14.11 similar to Reticulocalbin 1 precursor LOC253512 13q14.11 hypothetical protein LOC253512 LOC390401 13 similar to peptidyl-Pro cis trans isomerase COG3 13q14.11 component of oligomeric golgi complex 3 FLJ32682 13q14.11 hypothetical protein FLJ32682 LOC390402 13 similar to Aldose reductase (AR) (Aldehyde reductase) NURIT 13q14.11 testis-specific leucine zipper protein nurit LOC283514 13q14.11 similar to seven in absentia 2 KIAA0853 13q14.11 KIAA0853 CPB2 13q14.11 carboxypeptidase B2 (plasma, carboxypeptidase U) LCP1 13q14.3 lymphocyte cytosolic protein 1 (L-plastin) LOC220416 13q14.11 similar to Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8) LOC390403 13 similar to hypothetical protein FLJ20457 C13orf18 13q14.11 chromosome 13 open reading frame 18 LOC81993 13q14-q21 COX17 pseudogene CHDC1 13q14.11 calponin homology (CH) domain containing 1 ESD 13q14.1-q14.2 esterase D/formylglutathione hydrolase HTR2A 13q14.3 5-hydroxytryptamine (serotonin) receptor 2A SUCLA2 13q12.2-q13.3 succinate-CoA ligase, ADP-forming, beta subunit NUDT15 13q14.12 nudix (nucleoside diphosphate linked moiety X)-type motif 15 VDRIP 13q14.12 vitamin D receptor interacting protein ITM2B 13q14.3 integral membrane protein 2B RB1 13q14.2 retinoblastoma 1 (including osteosarcoma) P2RY5 13q14 purinergic receptor P2Y, G-protein coupled, 5 CHC1L 13q14.3 chromosome condensation 1-like CYSLTR2 13q14.12-p21.1 cysteinyl leukotriene receptor 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage hemopoietic cells
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • EPS15 homology domain
  • two actin-binding domains
  • four calponin homology domains
  • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY actin-binding protein family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION playing a role in hematopoietic cell differentiation and in the neoplastic process of some solid tumors
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • GCA (in a negative calcium dependant manner)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(3;13)(q27;q14) in B cell non-Hodgkin lymphoma translocation t(3;13)(q27;q14) in B cell non-Hodgkin lymphoma and in acute myoeloid leukemia
    tumoral     --over  
    in colorectal cancer in progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS