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FLASH GENE
Symbol LCP1 contributors: - updated : 24-06-2006
HGNC name lymphocyte cytosolic protein 1 (L-plastin)
HGNC id 6528
Location 13q14.3      Physical location : 46.700.058 - 46.756.459
Synonym name plastin 2
Synonym symbol(s) PLTL, CP64, PLS2, FLJ25423, FLJ26114, FLJ39956, L-PLASTIN
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage hemopoietic cells
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • EPS15 homology domain
  • two actin-binding domains
  • four calponin homology domains
  • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY actin-binding protein family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION playing a role in hematopoietic cell differentiation and in the neoplastic process of some solid tumors
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • GCA (in a negative calcium dependant manner)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(3;13)(q27;q14) in B cell non-Hodgkin lymphoma translocation t(3;13)(q27;q14) in B cell non-Hodgkin lymphoma and in acute myoeloid leukemia
    tumoral     --over  
    in colorectal cancer in progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS