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FLASH GENE
Symbol LCN6 contributors: - updated : 08-06-2006
HGNC name lipocalin 6
HGNC id 17337
Location 9q34.3      Physical location : 139.638.468 - 139.642.980
Synonym name
  • epididymal-specific lipocalin-6
  • lipocalin-5
  • Synonym symbol(s) LCN5, hLcn5, UNQ643
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389809 9 LOC389809 LHX3 9q34.3 LIM homeobox protein 3 QSCN6L1 9q34.3 quiescin Q6-like 1 AGS3 9q34.3 activator of G-protein signaling 3 LOC389810 9 LOC389810 CARD9 9q34.3 caspase recruitment domain family, member 9 SNAPC4 9q34.2-q34.3 small nuclear RNA activating complex, polypeptide 4, 190kDa SDCCAG3 9q34.3 serologically defined colon cancer antigen 3 PMPCA 9q34.3 peptidase (mitochondrial processing) alpha INPP5E 9q34.3 inositol polyphosphate-5-phosphatase, 72kDa KIAA0310 9q34.1 inositol polyphosphate-5-phosphatase, 72kDa FLJ36779 9q34.3 hypothetical protein FLJ36779 NOTCH1 9q34.3 Notch homolog 1, translocation-associated (Drosophila) LOC389811 9 similar to HSPC324 EGFL7 9q34.3 EGF-like-domain, multiple 7 AGPAT2 9q34.3 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) MGC20262 9q34.3 hypothetical protein MGC20262 MGC16037 9q34.3 hypothetical protein MGC16037 LCN6 9q34.3 lipocalin 6 LOC138307 LOC389812 LOC392401 9 similar to vacuolar H(+)-ATPase subunit; V-ATPase subunit; M16 MGC14141 9q34.3 hypothetical protein MGC14141 MGC15438 9q34.3 hypothetical protein MGC15438 FLJ10101 9q34.3 FLJ10101 protein LOC389813 9 similar to ENSANGP00000006371 PHP14 9q34.3 phosphohistidine phosphatase AEGP 9q34.3 apical early endosomal glycoprotein precursor EDF1 9q34.3 endothelial differentiation-related factor 1 TRAF2 9q34 TNF receptor-associated factor 2 FBXW5 9q34.3 F-box and WD-40 domain protein 5 C8G 9q22.33-q32 complement component 8, gamma polypeptide MGC48935 9q34.3 hypothetical protein MGC48935 LOC203235 9q34.3 hypothetical LOC203235 PTGDS 9q34.2-q34.3 prostaglandin D2 synthase 21kDa (brain) LOC286257 9q34.3 hypothetical protein LOC286257 CLIC3 9q34.3 chloride intracellular channel 3 ABCA2 9q34.3 ATP-binding cassette, sub-family A (ABC1), member 2 FUT7 9q34.3 fucosyltransferase 7 (alpha (1,3) fucosyltransferase) LOC389814 9 similar to LPAL6438 NPDC1 9q34.3 neural proliferation, differentiation and control, 1
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus  moderately
     male systemprostate  moderately
     male systemtestis  lowly
     male systemmale genital tractepididymis predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatozoa
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a predicted 20-amino acid signal peptide
  • multiple phosphorylation sites
  • secondary structure
  • beta-barrel structure
  • HOMOLOGY
    interspecies ortholog to rattus Lcn6
    ortholog to murine Lcn6
    Homologene
    FAMILY
  • lipocalin family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text
  • secreted
  • located on the head and tail of spermatozoa with the highest concentration on the post-acrosomal region of the head, where it appears aggregated into large patches
  • basic FUNCTION
  • may play a role in male fertility
  • acting as a prostaglandin-D synthase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • prostaglandin metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS