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FLASH GENE
Symbol LCN6 contributors: mct - updated : 16-10-2023
HGNC name lipocalin 6
HGNC id 17337
Location 9q34.3      Physical location : 139.638.468 - 139.642.980
Synonym name
  • epididymal-specific lipocalin-6
  • lipocalin-5
  • epididymis secretory sperm binding protein
    • Synonym symbol(s) LCN5, hLcn5, UNQ643
    DNA
    TYPE functioning gene
    STRUCTURE 4.51 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 708 - 163 - 2004 15363845
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus  moderately
     male systemmale genital tractepididymis predominantly Homo sapiens
     male systemtestis  lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatozoa Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a predicted 20-amino acid signal peptide
  • multiple phosphorylation sites
    • secondary structure
  • beta-barrel structure
    • HOMOLOGY
    interspecies ortholog to rattus Lcn6
    ortholog to murine Lcn6
    Homologene
    FAMILY
  • lipocalin family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text
  • secreted
  • located on the head and tail of spermatozoa with the highest concentration on the post-acrosomal region of the head, where it appears aggregated into large patches
    • basic FUNCTION
  • may play a role in male fertility
  • acting as a prostaglandin-D synthase
  • LCN6 is a novel lipocalin closely related to LCN8 and these genes are likely products of gene duplication events that predate rodent-primate divergence
  • predominant expression in the epididymis and location on sperm surface are consistent with a role for LCN6 in male fertility
  • may function as a transporter to carry ligands in the epididymal channel
  • LCN6, LCN8, LCN9, LCN10 epididymal secretory proteins are likely involved in ADAM3 maturation and acquisition of sperm fertilizing ability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • prostaglandin metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS