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FLASH GENE
Symbol LCMT1 contributors: mct - updated : 08-07-2015
HGNC name leucine carboxyl methyltransferase 1
HGNC id 17557
Location 16p12.1      Physical location : 25.123.046 - 25.189.551
Synonym name protein phosphatase methyltransferase 1
Synonym symbol(s) CGI-68, LCMT, PPMT1
EC.number 2.1.1.-
DNA
TYPE functioning gene
STRUCTURE 66.50 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SCNN1B 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) COG7 16p11.2 component of oligomeric golgi complex 7 GGA2 16p12 golgi associated, gamma adaptin ear containing, ARF binding protein 2 UBPH 16p12 similar to ubiquitin binding protein NDUFAB1 16p12.3-p12.1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa FLJ21816 16p12.3 hypothetical protein FLJ21816 MGC3248 16p12.3 dynactin 4 PLK LOC388226 16 similar to protein kinase/ribonuclease IRE1 beta ERN2 16p12.2 ER to nucleus signalling 2 LOC63928 16p12.3 hepatocellular carcinoma antigen gene 520 PRKCB1 16p12.1 protein kinase C, beta 1 CACNG3 16p13-p12.1 calcium channel, voltage-dependent, gamma subunit 3 RNU7P3 16p12.3 RNA, U7 small nuclear pseudogene 3 RBBP6 16p12-p11.2 retinoblastoma binding protein 6 TNRC6 16p12.1-p11.2 trinucleotide repeat containing 6 KST1 16p12.2-p11.2 trinucleotide repeat containing 6 RICH1 16p12-p11.2 Homo sapiens homolog of rat nadrin (RICH1), mRNA. LOC390685 16 hypothetical gene supported by BC041358 LOC342355 16p12.2 similar to hypothetical protein LOC388227 16 LOC388227 LCMT1 16p12.3-p12.1 leucine carboxyl methyltransferase 1 AQP8 16p12 aquaporin 8 LOC342357 16p12.2 similar to hypothetical protein FLJ35867 HCP39 16p12.2 cytochrome c, somatic pseudogene HS3ST4 16p11.2 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 EPF8 16p12.2 EPF8 pseudogene LOC390686 16 similar to ER degradation-enhancing alpha-mannosidase-like
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 1374 38 334 - 2011 21292165
  • isoform a
  • 9 splicing 1209 32 279 - 2011 21292165
  • isoform b
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure
  • active-site pocket recognizes the C-terminus of PPP2CA, and, interestingly, the PPP2CA active site makes extensive contacts to LCMT1
  • HOMOLOGY
    interspecies homolog to murine Lcmt1 (88.9pc)
    homolog to rattus Lcmt1 (88.9pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • underrepresented in the nucleus and mainly localizes to the cytoplasm, Golgi region and late endosomes
  • basic FUNCTION
  • involved in the methylation of the catalytic subunit of protein phosphatase 2A
  • is important for normal progression through mitosis and cell survival
  • potentially implicated in tight control of PPP2CA function, important for the cell cycle and cell survival
  • methylates the terminal carboxyl group of the leucine 309 residue of protein phosphatase 2A (PPP2CA), a key regulator of many cellular processes
  • the LCMT1-PPME1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GSK3B can inhibit PPP2CA by increasing the inhibitory L309-demethylation involving upregulation of PPME1 and inhibition of LCMT1
  • LCMT1 and protein phosphatase methylesterase-1 (PPME1) are essential enzymes that regulate the methylation of the protein phosphatase 2A catalytic subunit (PP2AC)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Lcmt1 knockout in mice is embryonic lethal