protein
| mediating phosphorylation of DOK proteins |
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interaction between PRKD2 and LCK (LCK regulated the activity of PRKD2 by tyrosine phosphorylation, which in turn may have modulated the physiological functions of PKD2 during TCR-induced T cell activation)  |
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anchoring CD4 to lipid microdomains (rafts) on microvilli |
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interacts with RASSF5 through its C-terminal Src homology 2 binding motif and LCK-mediated phosphorylation is critical for the efficient translocation of RASSF5 into the nuclear compartment  |
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SH2D2A through its interaction with both ITK and LCK, primes ITK for LCK mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements  |
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RHOH binds and modulates LCK, the non-receptor tyrosine kinase crucial in initiating pre-TCR and TCR signallings  |
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LAT promotes TCR signal initiation, suggesting that this adaptor may contribute to maintain active LCK in proximity of their substrates  |
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ITGB2 is constitutively associated with the protein tyrosine kinases LCK and ZAP70  |
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oncogenic LCK may activate LMO2 promoter through direct interaction  |
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oncogenic LCK and JAK2 may utilize different mechanisms to upregulate LMO2 levels during oncogenic transformation  |
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DLG1, which acts as a scaffold for many signaling molecules including the TCR and LCK, could mediate the cellular redistribution of LCK during T-cell maturation  |
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upregulates FOXP3 by tyrosine phosphorylation, resulting in decreased MMP9, SKP2, and VEGFA expression, and suppressed cellular invasion  |
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PTK2 negatively regulates LCK function downstream of the T cell antigen receptor  |
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spatial regulation of LCK by PTPRC and GM1 ganglioside determines the outcome of apoptotic response to LGALS1 and this local regulation may occur only upon intimate effector (LGALS1 expressing) cell-T-cell attachment  |
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prominent immunoregulatory function of LGALS1, is induction of apoptosis in activated T-cells by a process depending on the activity of SRC family tyrosine kinase, LCK  |
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both SLAMF6-associated LCK phosphorylation and kinase activity were enhanced in restimulated T cells, amplifying proximal TCR signaling  |
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SH2D1A facilitates recruitment and activation of LCK at SLAMF6 receptors during restimulation-induced cell death  |
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IGF2R specifically controls the balance between active and inactive LCK in resting T cells, which guarantees operative T cell effector functions  |
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in T-cells, cholesterol-dependent membrane domains function in the regulation of the Src family kinase LCK by sequestering LCK from its activator PTPRC  |
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in a kinase-independent manner, mitochondrial LCK interferes with mitochondrial translational machinery through competitive binding to GADD45GIP1  |