Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LCAT contributors: - updated : 24-06-2006
HGNC name lecithin-cholesterol acyltransferase
HGNC id 6522
Corresponding disease
FED Fish-Eye disease
LCAT lecithin, cholesterol acyltransferase deficiency
Location 16q22.1      Physical location : 67.973.786 - 67.978.015
EC.number 2.3.1.43
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D16S528E - LCAT LCAT - TAT TAT - PSMB10 - CTRL - PSKH1 - D16S124 - qter
Authors Frengen (95,97)
Physical map
TSNAXIP1 16q22.2 translin-associated factor X interacting protein 1 FLJ13111 16q22.1 hypothetical protein FLJ13111 THAP11 16q22.1 THAP domain containing 11 NUTF2 16q22.2 nuclear transport factor 2 RCD-8 16q22.1 autoantigen UNQ2446 16q22.1 MRCC2446 PSKH1 16q22.1 protein serine kinase H1 CTRL 16q22.1 chymotrypsin-like PSMB10 16q22.1 proteasome (prosome, macropain) subunit, beta type, 10 LCAT 16q22.1 lecithin-cholesterol acyltransferase SLC12A4 16q22.1 solute carrier family 12 (potassium/chloride transporters), member 4 DPEP3 16q22.1 dipeptidase 3 DPEP2 16q22.1 dipeptidase 2 LOC339065 16q22.1 similar to putative membrane-bound dipeptidase-2 DDX28 16q22.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 FLJ20399 16q22.1 hypothetical protein FLJ20399 NFATC3 16q22.1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   lowly
 stomach   moderately
Lymphoid/Immunespleen   moderately
Nervousbrain   lowly
Reproductivemale systemprostate  predominantly
Urinarybladder   highly
Visualeyeretina  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Lcat
ortholog to rattus Lcat
Homologene
FAMILY
  • AB hydrolase superfamily
  • lipase family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a central enzyme in the extracellular metabolism of plasma lipoproteins
  • invovlved in the esterification of the free cholesterol transported in plasma lipoproteins
  • converting cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high density lipoproteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling sensory transduction/vision
  • cholesterol metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LCAT , FED
    Susceptibility to familial combined hyperlipemia and premature coronary artery disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS