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FLASH GENE
Symbol LBP contributors: - updated : 02-02-2004
HGNC name lipopolysaccharide binding protein
HGNC id 6517
Location 20q11.23-q12      Physical location : 36.974.884 - 37.005.653
DNA
TYPE functioning gene
STRUCTURE 30.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
regionally located downstream of the BPI gene
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion serum,chylomicrons
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide,
  • a N terminal half with a LPS binding site,
  • four cysteine residues,
  • five glycosylation sites and
  • a conserved C terminal,with an octapeptide half required for anchoring lipoprotein particles
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY LBP/BPI/CETP family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular serum
    basic FUNCTION acute-phase protein specifically binding to the lipid A moiety of liposaceharide (LPS
    endotoxin) from the cell wall of Gram- bacteria
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein contributing with CD14 to the activation of the mitogen-activated protein kinase p38 by lipopolysaccharides in neutrophils
    cell & other associating with chylomicrons and enabling them to rapidly bind bacterial toxin
    REGULATION
    activated by oestradiol
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS