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FLASH GENE
Symbol LASP1 contributors: mct - updated : 14-01-2014
HGNC name LIM and SH3 protein 1
HGNC id 6513
Location 17q12      Physical location : 37.026.111 - 37.078.022
Synonym symbol(s) MLN50, EVI149, LASP-1
DNA
TYPE functioning gene
STRUCTURE 51.91 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TBC1D3 17q21.2 TBC1 domain family, member 3 LOC388379 17 similar to Puromycin-sensitive aminopeptidase (PSA) MRPL45 17q21.2 mitochondrial rbosomal protein L45 LOC342663 17q21.1 similar to mKIAA1136 protein NAP4 17q21.1 Nck, Ash and phospholipase C binding protein LOC388380 17 LOC388380 KIAA1501 17q21.1-q21.2 KIAA1501 protein KIAA1684 17q21.2 likely homolog of mouse p140 LOC390789 17 similar to RIKEN cDNA E130012A19 MLLT6 17q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 RNF110 12-12q22 ring finger protein 110 PSMB3 2q35 proteasome (prosome, macropain) subunit, beta type, 3 PIP5K2B 17q12 phosphatidylinositol-4-phosphate 5-kinase, type II, beta FLJ20291 17q21.2 hypothetical protein FLJ20291 LOC388381 17 LOC388381 RPL23 17q12 ribosomal protein L23 LASP1 17q12-q21 LIM and SH3 protein 1 LOC388382 17 hypothetical gene supported by BC009632; BC042124 FLJ43826 17q21.2 FLJ43826 protein PLXDC1 17q21.1 plexin domain containing 1 LOC390790 17 similar to Cg7197-prov protein CACNB1 17q21 calcium channel, voltage-dependent, beta 1 subunit RPL19 17q11 ribosomal protein L19 24b2/STAC2 17q21.2 24b2/STAC2 protein LOC388383 17 similar to upstream binding protein 1 MGC15482 17q21.2 F-box protein FBL2 PPARBP 17q12-q21.1 PPAR binding protein CRK7 17q21.2 CDC2-related protein kinase 7 NEUROD2 17p13.1 neurogenic differentiation 2 PPP1R1B 17q21.2 protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) STARD3 17q21.1 START domain containing 3 TCAP 17q12-q21.1 titin-cap (telethonin) PNMT 17q21.1 phenylethanolamine N-methyltransferase CAB2 17q21.2 CAB2 protein ERBB2 17q11.2-q12 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 4135 - 261 - 2008 18419822
6 - 4050 - 205 - 2008 18419822
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine   
Lymphoid/Immunelymph node   highly
Urinarykidneynephronrenal capsuleglomerulus Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • LIM (cysteine-rich LIM/double zinc finger motifs)
  • SH3 domains
  • an actin-binding domain in the core of the protein
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • localized in the cytoplasm and nuclei of tumor epithelia
  • predominantely present at focal adhesions, however, a second pool of LASP1 molecules is also found at lamellipodia and vesicle-like microdomains in the cytosol
  • basic FUNCTION
  • potentially involved in a signaling pathway for the organization of the cytoskeleton
  • may play an important role in the organization of focal adhesions with NEBL and ZYX
  • LASP1 and NEBL, are important during early embryo- and fetogenesis and are highly expressed in the central nervous system of the adult
  • NEBL and LASP1 have distinct roles in the actin cytoskeleton
  • role in chondrocyte differentiation during cartilage to bone transition
  • actin-binding, signaling pathway-regulated phosphoprotein that is overexpressed in several cancers
  • is potenbtially a general mediator of CXC chemokine mediated chemotaxis
  • functional role for LASP1 in the progression and metastatic dissemination of medulloblastoma
  • actin-binding protein that is known to regulate cytoskeleton architecture and cell migration
  • recruited in early steps of podosome assembly
  • multidomain protein predominantly localized at focal contacts, where it regulates cytoskeleton dynamics and cell migration
  • plays a significant role in the formation of several malignant tumours
  • actin-binding protein which is overexpressed in many types of cancers and plays important roles in cancer progression
  • may play an important role in the pathogenesis of esophageal squamous cell carcinoma(ESCC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel component and regulator of podosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • interacting with ZYX and NEBL (SH3 domains from LASP1 and nebulin can also interact with zyxin, but the SH3 domains from more distantly related proteins such as vinexin and SNX9 do not)
  • through Kelch repeats, KLHL41 interact directly with LASP1 in membrane ruffles at the tips of pseudopodia, where both proteins are necessary for pseudopodial elongation
  • LASP1 interaction with CXCR2 is critical for CXCR2-mediated chemotaxis
  • LASP1-binding partner, TJP2, having a role in the signal transduction pathway of LASP1 nucleo-cytoplasmatic shuttling
  • interplay between LASP2 and LASP1 could be an adhesion regulatory mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in breast cancer
    tumoral     --over  
    associated with poor overall survival in hepatocellular carcinoma patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    promise as a treatment target in esophageal squamous cell carcinoma
    cancerdigestive 
    might be a promising target in the treatment of patients with colorectal cancer (CRC) with growth and metastasis of CRC
    ANIMAL & CELL MODELS