basic FUNCTION
| trafficking between different subnuclear compartments |
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potential role in facilitating the synthesis of proteins required for cellular remodelling and migration |
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may have relevance in a number of conditions in which these processes are disrupted, such as in tissue regeneration and cancer |
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may be involved either directly or indirectly in an early stage of translation initiation |
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LARP1 may be involved in the post-transcriptional regulation of gene expression, at least in several 5'TOP mRNAs, through the binding to 3' terminus of the poly(A) tail |
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LARP1 is an important regulator of cell growth and proliferation |
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is a critical ancient mRNA-binding factor that evolved common as well as specific targets and regulatory functions in all eukaryotic lineages |
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by differentially regulating the stability of a selection of mRNAs, LARP1 promotes ovarian cancer progression and chemotherapy resistance |
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LARP1 serves as a phosphorylation-sensitive molecular switch for turning off or on RP mRNA translation and subsequent ribosome biogenesis |
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oncogenic RNA-binding protein required for ribosome biogenesis and cancer cell survival |
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CNBP and LARP1, two of the most strongly enriched viral RNA binders, restrict SARS-CoV-2 replication in infected cells |