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FLASH GENE
Symbol LARP1 contributors: mct - updated : 07-03-2022
HGNC name La ribonucleoprotein domain family, member 1
HGNC id 29531
Location 5q33.2      Physical location : 154.092.461 - 154.197.161
Synonym name
  • likely ortholog of mouse la related protein
  • la-related protein 1
  • Synonym symbol(s) LARP, KIAA0731, MGC19556
    DNA
    TYPE functioning gene
    STRUCTURE 134.63 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 6652 - 1019 - 2021 33332560
  • SI-LARP1
  • epigenetically repressed and that this repression is evolutionarily conserved in all but a small subclade of mammalian species (PMID: 32286153)
  • 17 - 7181 - 1096 - 2021 33332560
  • LI-LARP1 (PMID: 32286153)
  • 20 - 6540 - 891 - 2021 33332560
    19 - 6423 - 891 - 2021 33332560
    19 - 6324 - 858 - 2021 33332560
    19 - 6574 - 993 - 2021 33332560
    18 - 6222 - 824 - 2021 33332560
    19 - 7082 - 1063 - 2021 33332560
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RRM2 motifs, and La motif (LAM), in synergy with the immediately following RNA recognition motif (RRM)
  • two extremely well conserved motifs, named LSA and DM15, shared by LARP6 and LARP1 family members
  • a PAM2 motifs with variable affinities for the MLLE domain of PABPC1
  • C-terminal DM15 region binds the 7-methylguanosine (m7G) cap and 5' terminal oligopyrimidine (TOP) motif characteristic of transcripts encoding ribosomal proteins and translation factors
  • HOMOLOGY
    Homologene
    FAMILY
  • LARP family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • trafficking between different subnuclear compartments
  • potential role in facilitating the synthesis of proteins required for cellular remodelling and migration
  • may have relevance in a number of conditions in which these processes are disrupted, such as in tissue regeneration and cancer
  • may be involved either directly or indirectly in an early stage of translation initiation
  • LARP1 may be involved in the post-transcriptional regulation of gene expression, at least in several 5'TOP mRNAs, through the binding to 3' terminus of the poly(A) tail
  • LARP1 is an important regulator of cell growth and proliferation
  • is a critical ancient mRNA-binding factor that evolved common as well as specific targets and regulatory functions in all eukaryotic lineages
  • by differentially regulating the stability of a selection of mRNAs, LARP1 promotes ovarian cancer progression and chemotherapy resistance
  • LARP1 serves as a phosphorylation-sensitive molecular switch for turning off or on RP mRNA translation and subsequent ribosome biogenesis
  • oncogenic RNA-binding protein required for ribosome biogenesis and cancer cell survival
  • CNBP and LARP1, two of the most strongly enriched viral RNA binders, restrict SARS-CoV-2 replication in infected cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacts with PABP but also is in complex with the mRNA cap-binding protein EIF4E
  • PABPC1 is required for the association of LARP1 with its specific mRNA targets
  • LARP1 and LARP4 bind and protect mRNA 3' poly(A) tails from deadenylases through close contact with PABPC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular and lung cancers is correlated with adverse prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS