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FLASH GENE
Symbol LARP1 contributors: mct - updated : 23-12-2010
HGNC name La ribonucleoprotein domain family, member 1
HGNC id 29531
Location 5q33.2      Physical location : 154.092.461 - 154.197.161
Synonym name
  • likely ortholog of mouse la related protein
  • la-related protein 1
  • Synonym symbol(s) LARP, KIAA0731, MGC19556
    DNA
    TYPE functioning gene
    STRUCTURE 104.70 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 6644 - 1019 - 2004 15060081
    - - - - 1096 - 2010 20430826
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RRM2 motifs, and La motif (LAM), in synergy with the immediately following RNA recognition motif (RRM)
  • two extremely well conserved motifs, named LSA and DM15, shared by LARP6 and LARP1 family members
  • HOMOLOGY
    Homologene
    FAMILY
  • LARP family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • trafficking between different subnuclear compartments
  • potential role in facilitating the synthesis of proteins required for cellular remodelling and migration
  • may have relevance in a number of conditions in which these processes are disrupted, such as in tissue regeneration and cancer
  • may be involved either directly or indirectly in an early stage of translation initiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacts with PABP but also is in complex with the mRNA cap-binding protein EIF4E
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS