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FLASH GENE
Symbol LANCL2 contributors: mct - updated : 23-02-2013
HGNC name LanC lantibiotic synthetase component C-like 2 (bacterial)
HGNC id 6509
Location 7q31.2      Physical location : 55.433.140 - 55.501.433
Synonym name
  • testis-specific adriamycin sensivity protein
  • G protein-coupled receptor 69B
  • Synonym symbol(s) TASP, GPR69B
    DNA
    TYPE functioning gene
    STRUCTURE 68.29 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    SEC61G 7p11.2 phosphorylase kinase, gamma 1 (muscle) LOC392904 7 similar to calmodulin 1; Calmodulin 1 (phosphorylase kinase, delta) LOC346284 7p11.2 similar to Rho GTPase activating protein 5 LOC392905 7 similar to elongin A binding protein 1 LOC392673 7 similar to LanC lantibiotic synthetase component C-like 2; testis-specific adriamycin sensitivity protein; LanC (bacterial lantibiotic synthetase component C)-like 2; G protein-coupled receptor 69B EGFR 7p12 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) LANCL2 7q31.1-q31.33 LanC lantibiotic synthetase component C-like 2 (bacterial) DKFZP564K0822 7p11.2 hypothetical protein DKFZp564K0822 CALM1P2 7p11.2 calmodulin 1 (phosphorylase kinase, delta) pseudogene 2 LOC392031 7 similar to elongin A binding protein 1 LANCL2 7q31.1-q31.33 LanC lantibiotic synthetase component C-like 2 (bacterial) LOC392906 7 similar to cell division cycle 42 isoform 2; cell division cycle 42 (GTP-binding protein, 25kD); GTP-binding protein, 25kD; cell division cycle 42 (GTP binding protein, 25kD) LOC392907 7 similar to tubulin, beta 5 LOC392908 7 similar to KIAA0565 protein FKBP9L 7p11.1 FK506 binding protein 9-like DKFZP564K0822 7p11.2 hypothetical protein DKFZp564K0822 LOC392674 7 similar to SMT3 suppressor of mif two 3 homolog 2 LOC392675 7 similar to hypothetical protein LOC349114 LOC392909 7 similar to septin 10 isoform 1 LOC392032 7 similar to cell division cycle 42 isoform 2; cell division cycle 42 (GTP-binding protein, 25kD); GTP-binding protein, 25kD; cell division cycle 42 (GTP binding protein, 25kD) LOC392033 7 similar to tubulin, beta 5 FLJ39963 7p11.2 hypothetical protein FLJ39963 LOC392034 7 similar to KIAA0565 protein FKBP9L 7p11.1 FK506 binding protein 9-like MRPS17 7p11-q11.21 mitochondrial ribosomal protein S17 GBAS 7p12 glioblastoma amplified sequence LOC389491 7 similar to SMT3 suppressor of mif two 3 homolog 2 LOC389492 7 similar to hypothetical protein LOC349114 PSPH 7p15 phosphoserine phosphatase CCT6A 7q32-q33 chaperonin containing TCP1, subunit 6A (zeta 1) LOC346288 7p11.2 similar to septin 10 isoform 1 SUMF2 7q11.1 sulfatase modifying factor 2 PHKG1 7p12-q21 phosphorylase kinase, gamma 1 (muscle) C7orf17 7p11.2 chromosome 7 open reading frame 17 LOC392676 7 similar to Protein p8 (Candidate of metastasis 1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 44353 - 450 in brain 2001 11762191
    - - 4700 - - in brain 2001 11762191
    - - 1800 - - in testis 2001 11762191
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   moderately
     salivary gland   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
     nervecranial nerve  highly
    Reproductivefemale systemuteruscervix highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • unique N-terminus that function as the membrane anchor with a relevant N-terminal myristoylation and a basic phosphatidylinositol phosphate-binding site
  • a unique ATP/GTP-binding site motif A (P-loop)
  • HOMOLOGY
    interspecies homolog to rattus Lancl2 (88.6 pc)
    homolog to murine Lancl2 (89.5 pc)
    intraspecies homolog to LANCL1
    Homologene
    FAMILY
  • eukaryotic LanC-like protein family
  • lanthionine synthetase component C-like (LANCL) protein family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • major localization to the plasma membrane, juxta-nuclear vesicles, and the nucleus
  • basic FUNCTION
  • involved in the negative regulation of transcription
  • increasing cellular sensitivity to Adriamycin by decreasing the expression of P-gp
  • its overexpression enhances the cellular sensitivity to the anticancer drug adriamycin and this sensitivity is dependent on the myristoylation and membrane association of LANCL2
  • critical component of the abscisic acid (ABA) -sensing protein complex will enable the screening of synthetic ABA antagonists as prospective new anti-inflammatory and anti-diabetic agents
  • required for ABA binding to the plasma membrane of granulocytes and for the activation of the signaling pathway triggered by ABA in human granulocytes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a peptide-modifying complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • binding to ATP
  • binding to GTP
  • protein
    cell & other
    REGULATION
    activated by ABA, abscisic acid (ABA activates the human protein LANCL2 via direct bindin)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    being a bystander gene coamplified and overexpressed with epidermal growth factor receptor (EGFR) in approximately 20 pc of all glioblastomas
    constitutional     --over  
    interacts with the cortical actin cytoskeleton and therefore may play a role in cytoskeleton reorganization and in consequence to cell detachment
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS