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FLASH GENE
Symbol LANCL1 contributors: mct - updated : 28-03-2009
HGNC name LanC lantibiotic synthetase component C-like 1 (bacterial)
HGNC id 6508
Location 2q34      Physical location : 211.295.973 - 211.341.499
Synonym name
  • G protein-coupled receptor 69A
  • 40 kDa erythrocyte membrane protein p40
  • lanthionine synthase C-like protein-1
  • Synonym symbol(s) GPR69A, p40
    DNA
    TYPE functioning gene
    STRUCTURE 45.46 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure within the potential promoter regions, several consensus sequences for ubiquitous and tissue-specific transcription factors are present (Mayer 2001)
    MAPPING cloned Y linked   status confirmed
    Map cen - D2S355 - D2S154 - CPS1 - MYL1 - LANCL1 - ERBB4 - D2S371 - D2S143 - FN1 - D2S137 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2 and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4620 - 399 - Mayer (2001)
    - - 4531 - 399 - -
    - - 4526 - 399 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • seven transmembrane segments
  • seven highly conserved hydrophobic repeats
  • HOMOLOGY
    interspecies homolog to rattus Lancl1 (91.5 pc)
    homolog to murine Lancl1 (91.5 pc)
    homolog to a prokaryotic enzyme responsible for the synthesis of thioether (lanthionine) cross-linking within nascent polypeptide chains, yielding macrocyclic proteins with potent microbicidal activity (Chung 2007)
    Homologene
    FAMILY
  • G protein coupled receptor family
  • LanC-like protein family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the biosynthesis of antimicrobial peptides
  • glutathione binding protein possibly significant to neurodegenerative disease (Chung 2007)
  • may play a similar role as a peptide-modifying enzyme component in eukaryotic cells (Bauer 2000)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • G-protein coupled receptor protein signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the C-terminal of STOM
  • binding to low-density lipoprotein receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • SOD1G93A transgenic mice, a model for amyotrophic lateral sclerosis (ALS), wherein LanCL1 expression was found to be increased at presymptomatic stages of the disease (Chung 2007)
  • LANCL1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse (Nielsen 2003)