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FLASH GENE
Symbol LAMTOR5 contributors: mct/ - updated : 31-10-2012
HGNC name late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
HGNC id 17955
Location 1p13.3      Physical location : -
Synonym name
  • HBx-interacting protein
  • HBV X-interacting protein
  • hepatitis B virus x interacting protein
  • Synonym symbol(s) XIP, MGC71071, HBXIP
    DNA
    TYPE functioning gene
    STRUCTURE 6.67 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 855 18.03 173 - 2003 12773388
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineparathyroid   highly
    Nervousnervecranial nerve  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure dimer shows an extended beta-sheet area formed by 10 anti-parallel beta-strands from both subunits
    HOMOLOGY
    Homologene
    FAMILY
  • HBXIP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • plays a critical role in mitosis, particularly in centrosome duplication to form a bipolar spindle during prometaphase and in cytokinesis where replicating cells split to form two daughter cells at telophase
  • apoptosis initiated via the mitochondria/cytochrome c pathway
  • functioning as a cofactor for survivin, and serving as a link between the cellular apoptosis machinery and a viral pathogen involved in hepatocellular carcinogenesis
  • critical target of viral HBx for promoting genetic instability through formation of defective spindles and subsequent aberrant chromosome segregation
  • one of its functions is its involvement in cell proliferation
  • able to promote the proliferation of cells
  • able to enhance migration of breast cancer cells
  • promotes the proliferation and migration of breast cancer cells
  • LAMTOR5-activated the PTEN/PI3K/AKT signaling by inducing DNA methylation of PTEN, which subsequently boosted S100A4 expression
  • LAMTOR4, LAMTOR5 are two additional Ragulator components that are required for MTOR activation by amino acids
  • guanine nucleotide exchange factor (GEF) for the RAG GTPases
  • up-regulates SKP2 via activating E2F1 to promote proliferation of breast cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming survivin-HBXIP complexes that bind pro-caspase-9, preventing its recruitment to Apaf1, and thereby selectively suppressing apoptosis initiated via the mitochondria/cytochrome c pathway
  • can form a dimer that can indeed be found in the crystal when symmetric molecules are generated around the asymmetric unit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with viral HBx (binding to HBXIP is critical for the dysregulatory effects of HBx on mitotic spindle formation)
  • significantly stimulated the transcription and expression of TERT and increased the activity of telomerase in mesenchymal stem cells
  • interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx
  • upregulates CD46, CD55 and CD59 through p-ERK1/2/NFKB signaling to protect breast cancer from complement-dependent cytotoxicity
  • able to up-regulate S100A4 expression in breast cancer cells
  • able to stimulate the promoter of SKP2 through binding to the -640/-443 region in SKP2 promoter involving activating E2F transcription factor 1 (E2F1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the majority of non-small cell lung carcinoma, together with the abundant or upregulated expression of XIAP and BIRC5 suggest that tumours are endowed with resistance against a variety of apoptosis-inducing conditions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS