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FLASH GENE
Symbol LAMTOR1 contributors: mct - updated : 29-10-2015
HGNC name late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
HGNC id 26068
Location 11q13.4      Physical location : -
Genatlas name ragulator1
Synonym name
  • hypothetical protein LOC55004
  • chromosome 11 open reading frame 59
  • late endosome/lysosome membrane adaptor p18
  • Synonym symbol(s) FLJ20625, C11orf59, p18, PDRO, p27RF-Rho, Ragulator1
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1198 17 161 - 2012 22513874
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepancreas exocrine    
     salivary gland    
     stomach    
    Endocrinepancreas    
    Lymphoid/Immunelymph node    
    Reproductivefemale systembreastmammary gland  
     female systemovary   
     male systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the 60 C-terminal AAs are not required for interaction with LAMTOR2/LAMTOR3 heterodimer, in contrast to previously reported findings showing that truncation of 41 C-terminal AAs of LAMTOR1 prevents endosomal localization of LAMTOR2/LAMTOR3
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • attached to the endosomal surface by myristoyl and palmitoyl groups located at the N-terminus of the protein and tethers the signaling complex to the cytoplasmic surface of late endosomes
  • basic FUNCTION
  • lipid raft adaptor protein, involved in controlling endosome dynamics by anchoring the MAP2K1-ERK pathway to late endosomes
  • essential for anchoring the MEK-ERK pathway to late endosomes
  • serves as an anchor for MTOR and is required for its activation on lysosomes
  • its expression affects the tuning of lysosomal activation that can lead to TP53-dependent apoptosis through excessive catabolism
  • functions as a scaffold to recruit Rag GTPases to lysosomal membrane in MTOR signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component MTOR/LAMTOR1 pathway plays crucial roles in the late stages of lysosomal maturation, potentially in late endosome-lysosome fusion, which is required for processing of various macromolecules
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
  • is a binding partner of LAMTOR3/LAMTOR2
  • BORCS6 is a LAMTOR1-interacting protein that regulates MTOR activity through its interaction with LAMTOR1 at the lysosome
  • interaction of LAMTOR1 with Rag GTPases is required for their cellular co-localization and can be competitively inhibited by BORCS6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Lamtor1 (-/-) mice are embryonic lethal and have severe defects in endosome/lysosome organization and membrane protein transport in the visceral endoderm (the cells exhibit apparent defects in endosome dynamics through perinuclear compartment, such as aberrant distribution and/or processing of lysosomes)