Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol LAMA3 contributors: mct/npt/pgu - updated : 31-03-2010
HGNC name laminin, alpha 3
HGNC id 6483
Corresponding disease
EBJ1C epidermolysis bullosa, junctional , Herlitz type
EBJ2C epidermolysis bullosa junctional, non-Herlitz type
LOCS laryngo-onycho-cutaneous syndrome
Location 18q11.2      Physical location : 21.269.561 - 21.535.027
Synonym name
  • laminin alpha 3 compoment of the laminin 5 basement membrane protein
  • laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)
  • nicein-150kDa, kalinin-165kDa, BM600-150kDa, epiligrin
  • Synonym symbol(s) LAMNA, C3A6, E170, LAMA3A, BM600, Lm3B11, Lm3B21, Lm3B11
    TYPE functioning gene
    STRUCTURE 265.47 kb     76 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ROCK1 18q11.2 Rho-associated, coiled-coil containing protein kinase 1 LOC388471 18 similar to 60S RIBOSOMAL PROTEIN L21 LOC390839 18 similar to Endonuclease G like 1 (Endo G like) FLJ13687 EFO1 18q11.2 establishment factor-like protein SNRPD1 18q11.1 small nuclear ribonucleoprotein D1 polypeptide 16kDa ABHD3 18q11.1 abhydrolase domain containing 3 MIB 18q11.2 ubiquitin ligase mind bomb LOC201484 18q11.2 hypothetical LOC201484 GATA6 18q11.1-q11.2 GATA binding protein 6 CTAGE-1 18p11.2 CTAGE-1 protein CTAGE-2 18p11.2 CTAGE-2 LOC390840 18 similar to ribosomal protein S4, X-linked LOC390841 18 similar to ubiquitin-conjugating enzyme E2C isoform 2; ubiquitin carrier protein E2-C; ubiquitin-protein ligase C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme RBBP8 18q11.2 retinoblastoma binding protein 8 LOC91768 MGC11386 18q11.2 hypothetical protein MGC11386 RIOK3 18q11.2 RIO kinase 3 (yeast) C18orf8 18q11.2 chromosome 18 open reading frame 8 NPC1 18q11.1-q11.2 Niemann-Pick disease, type C1 LOC147463 18q11.2 hypothetical protein LOC147463 LOC390842 18 similar to 40S ribosomal protein S10 LAMA3 18q11.2 laminin, alpha 3 FLJ33761 18q11.2 hypothetical protein FLJ33761 CABYR 18q11.1 calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2) OSBPL1A 18q11-q12 oxysterol binding protein-like 1A IMPACT 18q11.2-q12.1 hypothetical protein IMPACT HRH4 18q11.2 histamine receptor H4 LOC390843 18 similar to hypothetical protein BC005868 LOC342741 18q11.2 similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 LOC147468 18q11.2 similar to WW domain binding protein 2 EHZF 18q11.2 early hematopoietic zinc finger SS18 18q11.2 synovial sarcoma translocation, chromosome 18 MGC26605 18q11.2 hypothetical protein MGC26605 TAF4B 18q11.2 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa KCTD1 18 potassium channel tetramerisation domain containing 1 LOC388472 18 hypothetical gene supported by BC002568 LOC342695 18q12.1 similar to ubiquitin fusion degradation 1-like AQP4 18q11.2.q12.1 aquaporin 4 FLJ30507 18q12.1 hypothetical protein FLJ30507 CHST9 18q11.2 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    38 splicing 5623 190.4 1724 placenta, pancreas, thymus, prostate, lung, colon, keratinocytes 2010 20805229
  • isoform 1 known as LAM Alpha 3a (LAMA3A)
  • differring in the 5' UTR and the 5' coding region compared to variant 1
  • containing exon 1b (shorter than 1a)
  • involved in tumour cell invasion and progression
  • initiated from an internal site in intron 38, encoding the N-terminally truncated laminin alpha3a protein
  • 76 splicing 10511 366.5 3333 highly expressed in placenta, lung, pancreas, and prostate, expressed in both endothelial and epithelial cells and in the in vascular basement menbrane 2010 20805229
  • isoform 1 known as LAM Alpha 3b (LAMA3B)
  • laminin-3B11, and laminin-3B21
  • containing exon 1a (longer than 1b)
  • containing exont 75a (longer than 75b)
  • encoding for the longest product
  • 37 - 5455 - 1668 - 2009 19773554
    74 - 10343 - 3277 - 2009 19773554
    10 - - 64 - placenta, testis, heart, lung, prostate, small intestine, leukocytes, keratinocytes 2009 19773554
  • also called LAMA3LN1
  • ex 1&
  • 65533;9 + 9e
  • LaNt (Laminin N terminus) alpha31
  • may play important roles in regulating laminin matrix functions and its expression is up-regulated during wound healing
  • 26 - - - 1039 placenta, liver thymus, prostate 2009 19773554
  • also called LAMA3LN2a
  • ex 1&
  • 65533;25 + 25e
  • LaNt alpha 32a (laminin N terminus)
  • may play important roles in regulating laminin matrix functions and its expression is up-regulated during wound healing
  • 12 - - - 994 liver, leukocytes 2009 19773554
  • also called LAMA3LN2b
  • ex 1&
  • 65533;9, 10&65533;25 + 25e
  • LaNt alpha32b (laminin N terminus)
  • may play important roles in regulating laminin matrix functions and its expression is up-regulated during wound healing
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon highly
     mouth   predominantly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemplacenta  highly
     male systemprostate  highly
    Respiratoryrespiratory tracttrachea  lowly
     respiratory tractlarynx  highly
    Skin/Tegumentskin   lowly
    Urinarykidney   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE) lowly
    SystemCellPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
    physiological period embryo
    Text early in developing embryo
  • three laminin A/neurexin/sex hormone-binding (LNS) globular domains
  • N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain
  • a N-terminal domain
  • a short stretch of laminin-type epidermal growth factor-like repeats
  • a long arm composed of heptad repeats typical of a cell alpha helical coiled-coil protein
  • five globular domains, binding to integrins and/or dystroglycan in the C terminal region
  • mono polymer heteromer , trimer
    interspecies homolog to murine Lama3 (78.13 pc)
    CATEGORY regulatory , structural protein
  • in the basement membrane
  • extracellular matrix, component of the basal lamina of kreatinocyte
  • basic FUNCTION
  • mediating the attachment, migration and organization of cells into tissues during embryonic development and key regulator of the granulation tissue response
  • CELLULAR PROCESS cell organization/biogenesis
    signaling signal transduction , sensory transduction/vision
    a component
  • constituent of cutaneous basement membrane zone
  • heterotrimerizing with laminin beta 3 and gamma 2 in laminin 5 (kalinin/nicein)
    small molecule
  • ITGA3
  • ITGA6
  • ITGB1
  • ITGB4
  • cell & other
    corresponding disease(s) EBJ1C , EBJ2C , LOCS
    Variant & Polymorphism
    Candidate gene
    Therapy target