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FLASH GENE
Symbol LAIR2 contributors: mct - updated : 14-03-2012
HGNC name leukocyte-associated Ig-like receptor 2
HGNC id 6478
Location 19q13.42      Physical location : 55.014.012 - 55.021.895
Synonym symbol(s) XXbac-BCX535A19.6, CD306
DNA
TYPE functioning gene
STRUCTURE 7.90 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map see FLNKR@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 702 - 152 - 2008 18209062
4 - 651 - 135 - 2008 18209062
EXPRESSION
Rna function
  • LAIR2 mRNA was found only in the more distal portions of trophoblast anchoring cell columns, adjacent to the invading extravillous trophoblast (EVT)
    • Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single Ig-like domain
  • a cytoplasmic tail
  • a immunoreceptor tyrosine based inhibitory motif (ITIM)
    • HOMOLOGY
    intraspecies homolog to LAIR1
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • may function as a natural competitor for LAIR1, thereby regulating its inhibitory potential
  • prevents binding of LAIR1 to collagens, suggesting that the protein has an immunoregulatory function
  • alterations in LAIR2 may play an etiologic role in preeclampsia
  • has the capacity to interfere with platelet-collagen interactions mediated by Glycoprotein VI and the VWF/Glycoprotein Ib axis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LAIR1 and LAIR2 bind several of these collagen-like peptides, with LAIR2 being able to bind more than LAIR1
  • binds collagen and can interfere with LAIR1/collagen interactions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    its levels are increased in synovial fluid of patients with rheumatoid arthritis as compared with osteoarthritis patients
    constitutional     --low  
    in the first trimester of pregnancies destined for preeclampsia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS