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FLASH GENE
Symbol LAIR2 contributors: mct - updated : 14-03-2012
HGNC name leukocyte-associated Ig-like receptor 2
HGNC id 6478
Location 19q13.42      Physical location : 55.014.012 - 55.021.895
Synonym symbol(s) XXbac-BCX535A19.6, CD306
DNA
TYPE functioning gene
STRUCTURE 7.90 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map see FLNKR@
Physical map
LILRB3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 ILT8 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 6 LILRB5 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 LILRB2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 LOC390971 19 similar to YME1-like 1; ATP-dependent metalloprotease FtsH1 LILRA3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 LIR9 19q13.4 leukocyte Ig-like receptor 9 LOC390972 19 similar to pheromone receptor ILT7 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4 LAIR1 19q13.4 leukocyte-associated Ig-like receptor 1 TTYH1 19q13.4 tweety homolog 1 (Drosophila) LENG8 19q13.42 leukocyte receptor cluster (LRC) member 8 LENG9 19q13.4 leukocyte receptor cluster (LRC) member 9 CDC42EP5 19q13.42 CDC42 effector protein (Rho GTPase binding) 5 LAIR2 19q13.4 leukocyte-associated Ig-like receptor 2 FLJ00060 19q13.42 hypothetical gene FLJ00060 LILRB1 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 LILRA2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 LILRA1 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 LILRB4 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 ILT9 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member6, pseudogene ILT10 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 5 KIR3DL7 19q13.42 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 5 KIR2DL3 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 LOC390973 19 similar to killer-cell Ig-like receptor KIR3DL7 KIR2DL1 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 LOC390974 19 similar to 1060P11.3 (killer inhibitory receptor 2-2-2 (KIR222) (KIRX))
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 702 - 152 - 2008 18209062
4 - 651 - 135 - 2008 18209062
EXPRESSION
Rna function
  • LAIR2 mRNA was found only in the more distal portions of trophoblast anchoring cell columns, adjacent to the invading extravillous trophoblast (EVT)
  • Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single Ig-like domain
  • a cytoplasmic tail
  • a immunoreceptor tyrosine based inhibitory motif (ITIM)
  • HOMOLOGY
    intraspecies homolog to LAIR1
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • may function as a natural competitor for LAIR1, thereby regulating its inhibitory potential
  • prevents binding of LAIR1 to collagens, suggesting that the protein has an immunoregulatory function
  • alterations in LAIR2 may play an etiologic role in preeclampsia
  • has the capacity to interfere with platelet-collagen interactions mediated by Glycoprotein VI and the VWF/Glycoprotein Ib axis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LAIR1 and LAIR2 bind several of these collagen-like peptides, with LAIR2 being able to bind more than LAIR1
  • binds collagen and can interfere with LAIR1/collagen interactions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    its levels are increased in synovial fluid of patients with rheumatoid arthritis as compared with osteoarthritis patients
    constitutional     --low  
    in the first trimester of pregnancies destined for preeclampsia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS