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FLASH GENE
Symbol LAIR1 contributors: mct - updated : 14-03-2012
HGNC name leukocyte-associated Ig-like receptor 1
HGNC id 6477
Location 19q13.42      Physical location : 54.865.234 - 54.876.721
Synonym symbol(s) LAIR-1, 9.1C3, XXbac-BCX403H19.4, CD305, LAIR-1
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 11.49 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see FLNKR@
Physical map
CACNG8 19q13.4 calcium channel, voltage-dependent, gamma subunit 8 CACNG6 19q13.4 calcium channel, voltage-dependent, gamma subunit 6 UNQ3033 19q13.42 LAIR hlog OSCAR 19q13.42 osteoclast-associated receptor NDUFA3 19q13.42 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa TFPT 19q13.4 TCF3 (E2A) fusion partner (in childhood Leukemia) PRPF31 19q13.42 PRP31 pre-mRNA processing factor 31 homolog (yeast) CNOT3 19q13.4 CCR4-NOT transcription complex, subunit 3 LENG1 19q13.4 leukocyte receptor cluster (LRC) member 1 TMC4 19q13.42 transmembrane channel-like 4 LENG4 19q13.4 transmembrane channel-like 4 LENG5 19q13.4 leukocyte receptor cluster (LRC) member 5 RPS9 19q13.4 ribosomal protein S9 LILRB3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 ILT8 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 6 LILRB5 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 LILRB2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 LOC390971 19 similar to YME1-like 1; ATP-dependent metalloprotease FtsH1 LILRA3 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 LIR9 19q13.4 leukocyte Ig-like receptor 9 LOC390972 19 similar to pheromone receptor ILT7 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4 LAIR1 19q13.4 leukocyte-associated Ig-like receptor 1 TTYH1 19q13.4 tweety homolog 1 (Drosophila) LENG8 19q13.42 leukocyte receptor cluster (LRC) member 8 LENG9 19q13.4 leukocyte receptor cluster (LRC) member 9 CDC42EP5 19q13.42 CDC42 effector protein (Rho GTPase binding) 5 LAIR2 19q13.4 leukocyte-associated Ig-like receptor 2 FLJ00060 19q13.42 hypothetical gene FLJ00060 LILRB1 19q13.4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 LILRA2 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 LILRA1 19q13.4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2816 32 287 - 1997 9285412
  • LAIR1-a
  • 9 splicing 2765 - 270 - 1997 9285412
  • LAIR1-b
  • - splicing 810 - 269 - 1997 9285412
    - splicing 950 - 209 - 1997 9285412
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text hematopoietic progenitor
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single Ig-like domain
  • a cytoplasmic tail
  • two immunoreceptor tyrosine-based inhibitory motifs (ITIM) in its cytoplasmic region
  • a collagen-binding domain, homologous to that of glycoprotein VI (GPVI), a collagen receptor crucial for platelet activation
  • HOMOLOGY
    intraspecies homolog to LAIR2
    Homologene
    FAMILY immunoglobulin (Ig) superfamily
    CATEGORY immunity/defense , signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • hematopoietic cell signaling, may be implicated in regulating hematopoiesis at early stage
  • negative regulator of natural killer (NK) cells
  • can function independently from SH2 domain-containing phosphatases and must recruit at least one other signaling molecule
  • regulated expression of LAIR1 and the subsequent change in the threshold for activation may be a mechanism to modulate inhibition of the immune system
  • receptor that potentially is able to regulate multiple steps of an immune response
  • collagen-receptor that inhibits immune cell function upon collagen binding
  • most widely spread immune receptors, attenuating immune cell activation when bound to specific sites in collagen
  • inhibitory function of LAIR1 may play a relevant role in the mechanisms controlling IFNA production by Plasmacytoid dendritic cells both in normal and pathological innate immune responses
  • inhibitory collagen receptor, that serves as a negative regulator of megakaryocytopoiesis
  • plays a role in regulating immune cells, suggesting that any adverse effects of its absence may be balanced in vivo by other inhibitory receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTPN6
  • phosphorylated LAIR1 bound the C-terminal SRC kinase (CSK) (interaction required the SH2 domain of CSK and phosphorylation of the tyrosine in the N-terminal ITIM of LAIR1)
  • LAIR2 may function as a natural competitor for LAIR1, thereby regulating its inhibitory potential
  • collagens act as ligands for the inhibitory receptor LAIR1, which inhibits the function of multiple types of immune cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS