Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LAD1 contributors: npt/ - updated : 02-11-2004
HGNC name ladinin 1
HGNC id 6472
Location 1q32.1      Physical location : 201.349.967 - 201.368.669
Synonym name
  • linear IgA disease antigen homolog
  • linear IgA bullous dermatosis antigen
  • Synonym symbol(s) LadA, MGC10355, Lad-1, LAD
    DNA
    TYPE functioning gene
    STRUCTURE 18.70 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2869 57 517 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    digestiveesophagus    
    Digestiveintestine    
     liver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Skin/Tegumentskin    
    Urinarybladder    
     kidneytubule   
     kidneynephron   
     ureter    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialbarrier/lininguroepithelium  
    Epithelialsecretoryglandularexocrine 
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a secretory signal sequence
  • several putative glycosylation sites
  • six SEK motifs which may participate in macromolecular interactions (Motoki 1997)
  • HOMOLOGY
    interspecies homolog to Mus cookii ladinin 1
    homolog to C.elegans F55F8.4
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text
  • extracellular matrix
  • localized to anchoring filaments underlying hemidesmosomes of the lamina lucida of the epidermal basement membrane
  • basic FUNCTION
  • contributing to the stability of the association of the epithelial layers with the underlying mesenchyme
  • maintaining dermal-epidermal cohesion
  • autoantigen associated with linear IgA disease (Motoki 1997)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the basement membranes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS