Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LACTB contributors: mct/npt - updated : 17-02-2010
HGNC name lactamase, beta
HGNC id 16468
Location 15q22.2      Physical location : 63.414.031 - 63.434.254
Synonym name
  • mitochondrial ribosomal protein L56
  • novel differentiation associated gene in keratinocytes (G24)
  • serine beta lactamase-like protein, mitochondrial
  • mitochondrial 39S ribosomal protein L56
  • Synonym symbol(s) MRPL56, G24, FLJ14902
    EC.number 3.4.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 20.22 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1956 60 547 - Clark, Koc (2001)
    5 splicing 1388 41 373 - Clark, Koc (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Reproductivemale systemprostate   
    Skin/Tegumentskin    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal transmenmbrane domain but no signal peptide
  • active site motif related to C-class beta lactamase
  • HOMOLOGY
    interspecies homolog to murine Lactb
    Homologene
    FAMILY
  • lactamase beta family
  • peptidase S12 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • protein from the large 39S subunit of the mitochondrial ribosome (mitoribosome)
  • mitochondrial protein sharing sequence similarity to the beta-lactamase/penicillin-binding protein family of serine proteases that are involved in bacterial cell wall metabolism (Liobikas (2006)
  • through polymerization, promotes intramitochondrial membrane organization and micro-compartmentalization (Polianskyte 2009)
  • can affect whole-organism energy homeostasis and therefore is directly or indirectly involved in the regulation of the metabolic circuitry (Polianskyte 2009)
  • can polymerize into stable filaments occupying the mitochondrial intermembrane space (LACTB filaments may play a role in submitochondrial organization and therefore possibly affect mitochondrial metabolon organization) (Polianskyte 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by HSPB1 in keratinocytes, associated with regulation of gene expression
    repressed by overexpression of HSPB1 during differentiation in normal keratinocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS