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FLASH GENE
Symbol LACRT contributors: npt/ - updated : 29-05-2006
HGNC name lacritin
HGNC id 16430
Location 12q13.2      Physical location : 55.024.622 - 55.028.663
Synonym name extracellular glycoprotein lacritin
Synonym symbol(s) MGC71934
DNA
TYPE functioning gene
STRUCTURE 4.04 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HOXC5 12q13.3 homeo box C5 LOC387863 12 LOC387863 SMUG1 12q13.11-q13.3 single-strand selective monofunctional uracil DNA glycosylase CBX5 12q12 chromobox homolog 5 (HP1 alpha homolog, Drosophila) HNRPA1 12q13.1 heterogeneous nuclear ribonucleoprotein A1 NFE2 12q13.1-q13.2 nuclear factor (erythroid-derived 2), 45kDa COPZ1 12q13.2-q13.3 coatomer protein complex, subunit zeta 1 GPR84 12q13.13 G protein-coupled receptor 84 ZNF385 12q13.13 zinc finger protein 385 ITGA5 12q11-q13 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) LOC387864 12 LOC387864 FLJ32942 12q13.13 hypothetical protein FLJ32942 HEM1 12q13.1 hematopoietic protein 1 PDE1B 12q13 phosphodiesterase 1B, calmodulin-dependent PPP1R1A 12q13.13 protein phosphatase 1, regulatory (inhibitor) subunit 1A LACRT 12q13 lacritin DCD 12q13.1 dermcidin VDAC5P 12 voltage-dependent anion channel 5, pseudogene LOC118430 12q small breast epithelial mucin KIAA0748 12q13.13 small breast epithelial mucin NEUROD4 12q13.13 neurogenic differentiation 4 LOC121360 12q13.13 similar to seven transmembrane helix receptor LOC341415 12q13.13 similar to Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2) LOC390317 12 similar to olfactory receptor MOR210-3 LOC390318 12 similar to olfactory receptor GA_x6K02T2LVGG-5968-6912
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 508 14.3 138 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 salivary gland    
Endocrinethyroid   moderately
Visualeyelacrimal gland   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion secretory fluid
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six putative O-glycosylation sites
  • an N-glycosylation site near the C terminus
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY secretory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secretory granules
    basic FUNCTION
  • augmenting lacrimal acinar cell secretion
  • promoting ductal cells proliferation
  • stimulating signaling through tyrosine phosphorylation and release of Ca2+
  • playing a role in the function of the lacrimal gland-corneal axis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • collagen IV
  • laminin-1
  • entactin/nidogen-1
  • fibronectin
  • vitronectin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS