basic FUNCTION
| chromatin-associated protein, effector of SUMO-dependent changes in chromatin structure and gene expression |
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preferentially recognize lower methylation states of several histone-derived peptides through its fourth MBT repeat |
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concerted action of both HDAC3 and L3MBTL2 in histone deacetylation and methylation-dependent transcriptional repression |
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acts in concert with PcG protein-mediated monoubiquitination of HIST2H2AC to establish a repressive chromatin structure |
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L3MBTL2 assembles an atypical Polycomb Repressive Complex1 (PRC1)-family complex that is essential in pluripotent stem cells and early development |
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L3MBTL2 plays a protective role in kidney injury, in part by inhibiting the DNA damage-TP53-apoptosis pathway |
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L3MBTL2 is a key target of RNF8 following DNA damage, demonstrating how the DNA damage response pathway is orchestrated by ubiquitin signalling |
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plays important roles in chromatin remodeling during meiosis and spermiogenesis |