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FLASH GENE
Symbol KTN1 contributors: - updated : 26-04-2006
HGNC name kinectin 1 (kinesin receptor)
HGNC id 6467
Location 14q22      Physical location : 56.046.924 - 56.151.301
Genatlas name coiled coil protein, same as KTN1
Synonym name CG-1 antigen
Synonym symbol(s) CG1, KNT, KIAA0004
DNA
TYPE functioning gene
STRUCTURE 104.00 kb     43 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
CDKN3 14q22 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) CNIH 14q22.1 cornichon homolog (Drosophila) GMFB 14q22.1 glia maturation factor, beta CGRRF1 14q22.1 cell growth regulator with ring finger domain 1 SAMD4 14q22.2 sterile alpha motif domain containing 4 GCH1 14q22.1-q22.2 GTP cyclohydrolase 1 (dopa-responsive dystonia) WDHD1 14q22.2 WD repeat and HMG-box DNA binding protein 1 SOCS7 14q22.2 suppressor of cytokine signaling 7 C14orf32 14q22.1 chromosome 14 open reading frame 32 LGALS3 14q21-q22 lectin, galactoside-binding, soluble, 3 (galectin 3) GALIG 14q21-q22 lectin, galactoside-binding, soluble, 3 (galectin 3) DLG7 14q22.1-q22.3 discs, large homolog 7 (Drosophila) UBE2L7 5p14.1 ubiquitin-conjugating enzyme E2L 7 pseudogene COX5AP1 14q22 cytochrome c oxidase subunit Va pseudogene 1 FBXO34 14q22.1 F-box only protein 34 KIAA0831 14q22.2 KIAA0831 HMGN1P1 14 high-mobility group nucleosome binding domain 1 pseudogene 1 LOC390477 14 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) SSH3BP1P 14 spectrin SH3 domain binding protein 1 pseudogene KTN1 14q22 kinectin 1 (kinesin receptor) LOC390479 14 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC387989 14 LOC387989 PELI2 14q21 pellino homolog 2 (Drosophila) C14orf101 14q22.2 chromosome 14 open reading frame 101 OTX2 14q21-q22 orthodenticle homolog 2 (Drosophila) LOC145414 14q22.3 similar to ribosomal protein L3; 60S ribosomal protein L3; HIV-1 TAR RNA-binding protein B LOC390480 14 similar to hypothetical protein FLJ22611
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemovary   
 male systemtestis   
Urinarybladder   highly
 kidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear localization signal (NLS)
  • interspersed heptad repeats
  • HOMOLOGY
    Homologene
    FAMILY ser/thr protein kinase family, iKAPPAb kinase subfamily
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • large integral ER membrane protein, phosphorylating inhibitors of NF-kappa-b thus leading to the dissociation of the inhibitor/NF-kappa-b complex and ultimately the degradation of the inhibitor
  • receptor for kinesin involved in kinesin-driven vesicle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with mavs/IPS1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS