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FLASH GENE
Symbol KSR2 contributors: - updated : 14-01-2012
HGNC name kinase suppressor of ras 2
HGNC id 18610
Location 12q24.22      Physical location : 117.890.816 - 118.406.028
Synonym symbol(s) FLJ25965
DNA
TYPE functioning gene
STRUCTURE 388.00 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D12S2079 - D12S1718 - KSR2 - D12S366 - D12S349 - pter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 17008 - 921 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one phorbol-ester/DAG-type zinc finger
  • one protein kinase domain
  • conjugated PhosphoP
    mono polymer dimer
    HOMOLOGY
    interspecies ortholog to Ksr2, Mus musculus
    ortholog to ksr2, Danio rerio
    ortholog to KSR2, Pan troglodytes
    Homologene
    FAMILY KSR family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • negatively regulates Cot-mediated MAP kinase and NF-kappaB pathway signaling (
  • a negative regulator of MEKK3-mediated activation of MAP kinase and NF-kappaB pathways, and concurrently inhibits MEKK3-mediated interleukin-8 production (
  • negative regulator of MEKK3-mediated activation of MAP kinase (specifically ERK and JNK) and NF-kappaB pathways, and concurrently inhibiting MEKK3-mediated interleukin-8 production
  • blocking MAP3K8 kinase activity and MAP3K8-mediated signaling
  • interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans (
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    text kinase activity (
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ion Zn2+
  • ATP (
  • protein
  • Ras, Raf, MEK-1, ERK-1/2 and Cot (
  • regulates the activity of MEKK3 (
  • mitogen-activated protein kinase kinase 1, MEK1 and BRAF (
  • cell & other
    REGULATION
    Other phosphorylated on Ser-353 by MARK3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS