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FLASH GENE
Symbol KRTAP10-10 contributors: - updated : 08-09-2005
HGNC name keratin associated protein 10-10
HGNC id 22972
Location 21q22.3      Physical location : 46.057.272 - 46.058.370
Synonym symbol(s) KAP10.10, KRTAP18.10
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, gene in gene
text located within introns of TSPEAR/c21orf29 gene, in a cluster of keratin-associated protein genes
STRUCTURE 1120.00 kb     1 Exon(s)
text structure
  • intronless gene
  • binding elements for the ETS, heat shock factor, AML, and HOX families of transcription factors
  • MAPPING cloned Y linked N status provisional
    Map cen - KRTAP10-1 - KRTAP10-2 - KRTAP10-3 - KRTAP10-4 - KRTAP10-5 - KRTAP10-6 - KRTAP10-7 - KRTAP10-8 - KRTAP10-9 - KRTAP10-10 - KRTAP10-11 - KRTAP12-4 - KRTAP12-3 - KRTAP12-2 - IMMTP - KRTAP12-1 - KRTAP10-12 - qter
    Authors Shibuya et al. (03)
    Physical map
    H2AFZP 21q22.3 H2A histone family, member Z, pseudogene PWP2H 21q22.3 PWP2 periodic tryptophan protein homolog (yeast) C21orf33 21q22.3 chromosome 21 open reading frame 33 C21orf32 21q22.3 chromosome 21 open reading frame 32 ICOSL 21q22.3 inducible T-cell co-stimulator ligand DNMT3L 21q22.3 DNA (cytosine-5-)-methyltransferase 3-like AIRE 21q22.3 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) PFKL 21q22.3 phosphofructokinase, liver C21orf2 21q22.3 chromosome 21 open reading frame 2 TRPM2 21q22.3 transient receptor potential cation channel, subfamily M, member 2 LRRC3 21q22.3 leucine-rich repeat-containing 3 C21orf29 21q22.3 chromosome 21 open reading frame 29 C21orf90 21q22.1 chromosome 21 open reading frame 90 KRTAP10-10 21q22.3 keratin associated protein 10-10 KRTAP12-2 21q22.3 keratin associated protein 12-2 IMMTP 21q22.3 inner membrane protein, mitochondrial (mitofilin) pseudogene KRTAP12-1 21q22.3 keratin associated protein 12-1 UBE2G2 21q22.3 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) SMT3H1 21q22.3 SMT3 suppressor of mif two 3 homolog 1 (yeast) PTTG1IP 21q22.3 pituitary tumor-transforming 1 interacting protein ITGB2 21q22.3 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) C21orf69 21q22.3 chromosome 21 open reading frame 69 C21orf67 21q22.3 chromosome 21 open reading frame 67 C21orf70 21q22.3 chromosome 21 open reading frame 70 LOC391283 21 similar to interspersed repeat antigen, putative C21orf122 21q22.3 chromosome 21 open reading frame 122 ADARB1 21q22.3 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin appendageshairbulb  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    several intragenic repeats
    HOMOLOGY
    Homologene
    FAMILY high sulfur keratin associated proteins 10/18
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • essential for the formation of a rigid and resistant hair shaft
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with hair keratins
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS