Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KRT76 contributors: mct/npt - updated : 27-06-2022
HGNC name keratin 76
HGNC id 24430
Location 12q13.13      Physical location : 53.161.939 - 53.171.129
Synonym name
  • cytokeratin 2
  • keratin 2p
  • keratin, type II cytoskeletal 2 oral
  • type-II keratin Kb9
  • Synonym symbol(s) HUMCYT2A, KRT2B, KRT2P, K2P
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text keratin clusters on chromosomes 12 (type II)
    STRUCTURE 9.19 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2529 65.7 638 - 2005 15737194
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly Homo sapiens
     mouthpalate  highly Homo sapiensFetal
     mouthtongue  highly Homo sapiensFetal
     stomach   highly Homo sapiens
     stomach   highly Homo sapiensFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum basale  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Krt76
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    basic FUNCTION
  • major cytoskeletal protein, having structural molecule activity
  • is required for tight junction function and maintenance of the skin barrier
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two type I and two type II keratins, keratin 8 associates with keratin 18
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KRT76 interacts with CLDN1 and likely this interaction is necessary to correctly position CLDN1 in tight junctions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in human oral squamous cell carcinomas (OSCC) correlates with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • genetic ablation of Krt76 in mice leads to spleen and lymph node enlargement, an increase in regulatory T cells (Tregs) and high levels of pro-inflammatory cytokines