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FLASH GENE
Symbol KRT75 contributors: npt/mct - updated : 20/10/2008
HGNC name keratin 75
HGNC id 24431
Location 12q13      Physical location : 52.817.853 - 52.828.110
Synonym name
  • type II keratin-K6hf
  • keratin, type II cytoskeletal 75
  • keratin-6 hair follicle
  • type II keratin-18
  • cytokeratin-75
    • Synonym symbol(s) K6HF, KB18
    DNA
    TYPE functioning gene
    STRUCTURE 10.30 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2125 59 551 - Schweizer (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    intraspecies homolog to KRT5
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION plays an essential role in hair and nail formation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two type I and two type II keratins, keratin 8 associates with keratin 18
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to pseudofolliculitis barbae (PFB), OMIM612318
    Variant & Polymorphism other polymorphisms associated to pseudofolliculitis barbae (PFB)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS