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FLASH GENE
Symbol KRT74 contributors: npt/mct - updated : 28-11-2018
HGNC name keratin 74
HGNC id 28929
Corresponding disease
ADWH woolly hair disorder
HTSS4 hypotrichosis simplex of the scalp 4
Location 12q13.13      Physical location : 52.959.602 - 52.967.609
Synonym name
  • keratin 5c
  • keratin 6 irs4
  • type II inner root sheath-specific keratin-K6irs4
  • keratin, type II cytoskeletal 74
    • Synonym symbol(s) KRT5C, KRT6IRS4, K6IRS4, KB37, ADWH, HTSS4, HYPT3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text subclustered in the type II keratin/hair keratin gene domain
    STRUCTURE 8.01 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2799 - 529 - 2014 24714551
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text specifically expressed in the Huxley layer
    basic FUNCTION formed a branch separate from the other epithelial and hair keratins
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADWH , HTSS4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS