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FLASH GENE
Symbol KRT71 contributors: npt/mct - updated : 28-11-2018
HGNC name keratin 71
HGNC id 28927
Corresponding disease
ADWH2 woolly hair disorder with hypotrichosis 2
Location 12q13.13      Physical location : 52.937.693 - 52.946.931
Synonym name
  • keratin 6 irs
  • cytokeratin-71
  • type II keratin-34
  • type II inner root sheath-specific keratin-K6irs1
  • keratin, type II cytoskeletal 71
    • Synonym symbol(s) K6IRS1, KRT6IRS, KB34, MGC119390, MGC119391
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with other type II cytokeratins
    STRUCTURE 9.24 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2238 57 523 - 2012 22592156
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunethymus    
    Skin/Tegumentskin appendageshairfollicle specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine K6irs
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION specifically expressed in the inner root sheath cuticle, and delayed up to the height of the apex of the dermal papilla
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADWH2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS