Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KRT7

contributors: mct/npt - updated : 07-06-2008

HGNC name	keratin 7
HGNC id	6445

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q13      Physical location : 52.626.953 - 52.642.709
Synonym name	sarcolectin
	cytokeratin 7
	keratin, 55K type II cytoskeletal
	human mesothelial keratin K7 (type II) mRNA, 3' end
Synonym symbol(s)	K2C7, SCL, CK7, MGC129731, MGC3625

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	15.75 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 9 - 1753 51.4 469 - Judson (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine neuroendocrine pituitary         pancreas         Reproductive female system ovary     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved central rod domain, made of four helical domains (1A, 1B, 2A, 2B) interrupted by non alpha helical linkers (L1, 2, 3)
	flanked by the homology domains H1 and H2, by variable region (V1, V2) and end sequences (E1, E2)

mono polymer

heteromer , tetramer

HOMOLOGY

Homologene

FAMILY	intermediate filament family
	type II keratin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament
	intracellular,nuclear envelope

basic FUNCTION	primordial component of the cytoskeleton and the nuclear envelope
	functioning in balance with interferons (IFNs) that can inhibit growth and affect cell differentiation
	activating peripheral blood mononuclear cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS