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FLASH GENE
Symbol KRT6C contributors: npt/mct - updated : 20/10/2008
HGNC name keratin 6C
HGNC id 20406
Location 12q12-q13      Physical location : 52.862.300 - 52.867.569
Synonym name
  • keratin 6E
  • keratin, type II cytoskeletal 6C
  • keratin K6h
  • cytokeratin-6C
  • Synonym symbol(s) K6C, CK6C, KRT6E, MGC102925, MGC163455, MGC163457, K6E
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with other type II cytokeratins
    STRUCTURE 5.27 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2345 60 564 - Schweizer (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    digestiveesophagus    
    Digestivepharynx   highly
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin appendageshairfollicle  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Krt2-6a
    homolog to chimpanzee LOC451918
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text expressed with family members KRT16 and/or KRT17
    basic FUNCTION
  • neutral protein arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of a type I (acidic) and a type II (neutral to basic) keratin
  • dimerizing with KRT16 and/or KRT17
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to KRT16, KRT17
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS