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FLASH GENE
Symbol KRT34 contributors: mct/npt - updated : 01/10/2008
HGNC name keratin 34
HGNC id 6452
Location 17q12-q21      Physical location : 39.533.922 - 39.538.636
Synonym name
  • keratin, hair, acidic, 4
  • hair keratin, type I Ha4
  • keratin, type I cuticular Ha4
    • Synonym symbol(s) HHA4, KRTHA4, HKA4, HA4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.72 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located clustered with other acidic hair keratins in a region spanning 190kb
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1713 - 436 - Ewing (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text differentiating hair cortical cells during anagen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal cystine-rich domain
  • a central rod domain composed of four alpha helical coiled-coil repeats separated by linker region
  • a C terminal globular region
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • structural constituent of cytoskeleton activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS