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FLASH GENE
Symbol KRT24 contributors: mct/npt - updated : 11-06-2024
HGNC name keratin 24
HGNC id 18527
Location 17q21.2      Physical location : 38.854.243 - 38.860.002
Synonym name
  • cytokeratin-24
  • keratin, type I cytoskeletal 24
  • CDNA FLJ20261 fis, clone COLF7630
    • Synonym symbol(s) MGC138173, MGC138169, FLJ20261, KA24
    DNA
    TYPE functioning gene
    STRUCTURE 5.76 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1883 55.1 525 - 2017 28362807
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouth   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunespleen   highly
     thymus    
    Reproductivefemale systemplacenta  highly
    Visualeye   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Krt24 (75.2pc)
    homolog to rattus Ka24 (75.3pc)
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • epithelial keratins associated with simple/glandular or stratified, non-cornified epithelia
  • KRT24 may be suggested as a potential differentiation marker and anti-proliferative factor in the epidermis 7)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other UV radiation may promote the modulation of KRT24 and MMP9 pterygium-related genes and induce the initiation and progression of ocular pterygium
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to colorectal cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS