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FLASH GENE
Symbol KRT23 contributors: mct/npt - updated : 27/09/2008
HGNC name keratin 23 (histone deacetylase inducible)
HGNC id 6438
Location 17q21.2      Physical location : 39.078.951 - 39.093.836
Synonym name
  • cytokeratin 23
  • keratin, type I cytoskeletal 23
  • hyperacetylation-inducible type I keratin
  • Synonym symbol(s) K23, DKFZP434G032, HAIK1, CK23, MGC26158
    DNA
    TYPE functioning gene
    STRUCTURE 14.90 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KRT25B 17q21.2 keratin 25B KRT25A 17q21.2 keratin 25A KRT25C 17q21.2 keratin 25C KRT25D 17q21.2 keratin 25C MGC21518 17q21.2 hypothetical protein MGC21518 KRT12 17q21.1 keratin 12 (Meesmann corneal dystrophy) KRT20 17q21.2 keratin 20 KRT23 17q21.2 keratin 23 (histone deacetylase inducible) LOC390792 17 similar to type I hair keratin 6 FLJ36600 17q21.2-q21.31 hypothetical protein FLJ36600 KRTAP3-3 17q12-q21 keratin associated protein 3-3 KRTAP3-2 17q12-q21 keratin associated protein 3-2 KRTAP3P1 17q12-q21 keratin associated protein 3 pseudogene 1 KRTAP3-1 17q12-q21 keratin associated protein 3-1
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing results in multiple transcripts variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 2163 48 422 - Zhang, Schweizer (2006)
    - splicing 1474 - 209 - Zhang, Schweizer (2006)
    variant 2 has an alternative segment in 5'UTR, lacking a coding exon and using a downstream start codon. Isoform b has a shorter N-terminus as compared to isoform a
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a rod domain
  • mono polymer heteromer , tetramer , complex
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • responsible for the structural integrity of epithelial cells
  • epithelial keratins associated with simple/glandular or stratified, non-cornified epithelia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by thrichostatin A
    histone deacetylase inhibitors (sodium butyrate NaBu) in pancreatic cancer cells
    p21 (itself induced by Nabu)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS