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FLASH GENE
Symbol KRT15 contributors: mct/npt - updated : 05-06-2019
HGNC name keratin 15
HGNC id 6421
Location 17q21-q23      Physical location : 39.669.997 - 39.675.270
Synonym name
  • cytokeratin 15
  • type I cytoskeletal 15
  • keratin-15, basic
  • keratin-15, beta
    • Synonym symbol(s) K15, CK15, K1CO, KRTB
    DNA
    TYPE functioning gene
    STRUCTURE 5.14 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    motif
    text structure
  • regulators of K15 promoter activity are transcription factors C/EBP, AP-1, and NF-kappaB, nuclear receptors for thyroid hormone, retinoic acid, and glucocorticoids, and the cytokine gamma interferon IFNG (C/EBP-beta and AP-1 induced, while retinoic acid, glucocorticoid receptors, and NF-kappaB suppressed, the KRT15 promoter)
    • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1709 49.2 456 - Radoja (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   predominantly
     mouthtongue  highly
    Reproductivefemale systembreastmammary gland highly
     male systemprostate  highly
    Respiratorylung   moderately
     respiratory tractlarynx  highly
     respiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningcorneal epithelium moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • conserved central rod domain, with four helical domains (1A, 1B, 2A, 2B)
  • interrupted by non alpha helical linkers (L1, 2, 3)
  • flanked by the homology domain H1, by variable region (V1, V2) and end sequences (E1, E2)
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Ka15 (89.86 pc)
    homolog to murine Krt15 (89.53 pc)
    Homologene
    FAMILY
  • type I keratin family
  • intermediate filament family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • being responsible for the structural integrity of epithelial cells
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text epidermal differentiation
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two type I (acidic) and two type II (neutral to basic) keratins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • type I & II keratins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the Prostate carcinoma compared to the benign prostatic hyperplasia (BPH)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS